A Case Control Study on Serum Levels of Potential Biomarkers in Male Breast Cancer Patients

Kamal Eldin Ahmed Abdelsalam, Mohammed Asad, Monjid Ahmed Ibrahim Ahmed, Syed Mohammed Basheeruddin Asdaq, Yahya Mohzari, Ahmed Alrashed, NajwaJilan Alghamdi, Kholoud Nasser Alrami and Wael Ahmed Alharbi
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Kamal Eldin Ahmed Abdelsalam: Department of Clinical Laboratory Science, College of Applied Medical Sciences, Shaqra University, Shaqra 11911, Saudi Arabia
Mohammed Asad: Department of Clinical Laboratory Science, College of Applied Medical Sciences, Shaqra University, Shaqra 11911, Saudi Arabia
Monjid Ahmed Ibrahim Ahmed: Department of Clinical Laboratory Science, College of Applied Medical Sciences, Shaqra University, Shaqra 11911, Saudi Arabia
Syed Mohammed Basheeruddin Asdaq: Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Dariyah, Riyadh 13713, Saudi Arabia
Yahya Mohzari: Clinical Pharmacy Department, King Saud Medical City, Riyadh 12746, Saudi Arabia
Ahmed Alrashed: Pharmaceutical Services Administration, Inpatient Department, Main Hospital, KFMC, Riyadh 11564, Saudi Arabia
NajwaJilan Alghamdi: Department of Pharmacy, Adham General Hospital, Adham 28653, Saudi Arabia
Kholoud Nasser Alrami: Pharmaceutical Services Department, King Fahad Medical City, Riyadh 11564, Saudi Arabia
Wael Ahmed Alharbi: Pharmaceutical Services Department, King Fahad Medical City, Riyadh 11564, Saudi Arabia

IJERPH, 2021, vol. 18, issue 9, 1-9

Abstract: The global incidence of breast cancer among men is steadily growing. Despite this, compared to female breast cancer patients, there are very few studies on biomarkers in male breast cancer patients. A cross-sectional case control study was carried out to determine the serum levels of melatonin, ghrelin, dopamine, serotonin, epinephrine, and GABA in male breast cancer. All the recruited patients were obese, old, and had recently been diagnosed with the disease. They had not received any treatment for the cancer until the time of the study. Melatonin and epinephrine serum levels were significantly higher in breast cancer patients compared to their age-matched controls, whereas ghrelin, dopamine, GABA, and serotonin serum levels were lower in patients compared to the control group. The serum levels of most of the studied biomarkers in male breast cancer patients were similar to those observed in female breast cancer patients, except for serum melatonin levels.

Keywords: dopamine; epinephrine; GABA; ghrelin; melatonin; serotonin (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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