Co-Circulation of Bovine Leukemia Virus Haplotypes among Humans, Animals, and Food Products: New Insights of Its Zoonotic Potential

Adriana P. Corredor-Figueroa, Nury N. Olaya-Galán, Sebastian Velandia-Álvarez, Marina Muñoz, Sandra P. Salas-Cárdenas, Milcíades Ibáñez-Pinilla, Manuel A. Patarroyo and Maria F. Gutiérrez
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Adriana P. Corredor-Figueroa: Grupo de Enfermedades Infecciosas, Laboratorio de Virología, Departamento de Microbiología, Pontificia Universidad Javeriana, Bogota 110231, Colombia
Nury N. Olaya-Galán: Grupo de Enfermedades Infecciosas, Laboratorio de Virología, Departamento de Microbiología, Pontificia Universidad Javeriana, Bogota 110231, Colombia
Sebastian Velandia-Álvarez: Grupo de Enfermedades Infecciosas, Laboratorio de Virología, Departamento de Microbiología, Pontificia Universidad Javeriana, Bogota 110231, Colombia
Marina Muñoz: Centro de Investigaciones en Microbiología y Biotecnología-UR (CIMBIUR), Facultad de Ciencias Naturales, Universidad del Rosario, Bogota 111221, Colombia
Sandra P. Salas-Cárdenas: Grupo de Enfermedades Infecciosas, Laboratorio de Virología, Departamento de Microbiología, Pontificia Universidad Javeriana, Bogota 110231, Colombia
Milcíades Ibáñez-Pinilla: Research Department, Hospital Universitario Mayor Méderi—Universidad del Rosario, Bogota 111411, Colombia
Manuel A. Patarroyo: Molecular Biology and Immunology Department, Fundación Instituto de Inmunología de Colombia (FIDIC), Bogota 111321, Colombia
Maria F. Gutiérrez: Grupo de Enfermedades Infecciosas, Laboratorio de Virología, Departamento de Microbiología, Pontificia Universidad Javeriana, Bogota 110231, Colombia

IJERPH, 2021, vol. 18, issue 9, 1-14

Abstract: Bovine leukemia virus (BLV) is the causative agent of leukemia/lymphoma in cattle. It has been found in humans and cattle-derived food products. In humans, it is described as a potential risk factor for breast cancer development. However, the transmission path remains unclear. Here, a molecular epidemiology analysis was performed to identify signatures of genetic flux of BLV among humans, animals, and food products. Sequences obtained from these sources in Colombia were used ( n = 183) and compared with reference sequences available in GenBank. Phylogenetic reconstruction was performed in IQ-TREE software with the maximum likelihood algorithm. Haplotype (hap) distribution among the population was carried out with a median-joining model in Network5.0. Recombination events were inferred using SplitsTree4 software. In the phylogenetic analysis, no specific branches were identified for the Colombian sequences or for the different sources. A total of 31 haps were found, with Hap 1, 4, 5 and 7 being shared among the three sources of the study. Reticulation events among the different sources were also detected during the recombination analysis. These results show new insights about the zoonotic potential of BLV, showing evidence of genetic flux between cattle and humans. Prevention and control strategies should be considered to avoid viral dissemination as part of the One Health program policies.

Keywords: molecular epidemiology; bovine leukemia virus; haplotypes; zoonoses; recombination analysis (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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