Effects of Serum Vitamin D Levels and Vitamin D Supplementation on Urticaria: A Systematic Review and Meta-Analysis

Yajia Li, Ziqin Cao, Jia Guo, Qiangxiang Li and Juan Su
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Yajia Li: Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China
Ziqin Cao: Department of Spine Surgery, Xiangya Hospital, Central South University, Changsha 410008, China
Jia Guo: Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China
Qiangxiang Li: National Clinical Research Center for Geriatric Disorders of Xiangya Hospital, Central South University (Sub-center of Ningxia), Yinchuan 750001, China
Juan Su: Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China

IJERPH, 2021, vol. 18, issue 9, 1-14

Abstract: (1) Backgrounds: Several studies have shown that the level of 25-hydroxyvitamin D (25(OH)D) could affect urticaria. The association of Vitamin D (VitD) with urticaria has not been well established. (2) Methods: The up-to-date meta-analysis was performed to synthesize the new findings. We performed a systematic search in PubMed, EMBASE, Web of Science, and Cochrane Database. We included the observational studies with the comparisons of 25(OH)D between urticarial populations and controls and clinical studies with the clinical severity of urticaria records. (3) Results: A meta-analysis of seventeen studies of urticaria group vs. controls revealed a mean difference of ?9.35 ng/mL (95% CI ?12.27 to ?6.44). There was also an association of urticaria with VitD deficiency. In the subgroup analysis of age and disease type, significant effects of 25(OH)D were found among adult and chronic urticarial populations. Six VitD supplementation trials showed a significant reduction in clinical urticarial score on intervention with VitD with the standard mean difference of ?3.63 and ?1.54 among randomized control studies and repeated measure trials, respectively. (4) Conclusions: The urticarial population, especially the adult chronic urticarial patients, may be associated with a high risk for lower serum 25(OH)D. VitD supplementations could result in a reduction of urticarial clinical symptoms.

Keywords: urticaria; vitamin D; supplementation; systematic review; meta-analysis (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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