Progression of Metabolic Syndrome Components along with Depression Symptoms and High Sensitivity C-Reactive Protein: The Bogalusa Heart Study

Azad R. Bhuiyan, Marinelle Payton, Amal K. Mitra, Sophia S. Leggett, Jihua Xu, Paul B. Tchounwou and Frank Smart
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Azad R. Bhuiyan: School of Public Health, College of Health Sciences, Jackson State University, Jackson, MS 39213, USA
Marinelle Payton: School of Public Health, College of Health Sciences, Jackson State University, Jackson, MS 39213, USA
Amal K. Mitra: School of Public Health, College of Health Sciences, Jackson State University, Jackson, MS 39213, USA
Sophia S. Leggett: School of Public Health, College of Health Sciences, Jackson State University, Jackson, MS 39213, USA
Jihua Xu: Louisiana Health Sciences Center, New Orleans, LA 70112, USA
Paul B. Tchounwou: College of Science, Engineering, and Technology, Jackson State University, Jackson, MS 39217, USA
Frank Smart: Louisiana Health Sciences Center, New Orleans, LA 70112, USA

IJERPH, 2021, vol. 18, issue 9, 1-14

Abstract: This study examined the association between depression symptoms and metabolic syndrome (MetS) or its components prospectively. It assessed the mediator role of high-sensitivity C-reactive protein (hs-CRP) and intracellular adhesion molecule-1 (ICAM-1). Self-reported depression symptoms were assessed using the Center for Epidemiologic Studies-Depression scale. MetS was defined as having at least three of the following five criteria: (1) waist circumference >102 centimeters (cm) in men or >88 cm in women; (2) triglycerides ? 50 milligrams per deciliter (mg/dL); (3) high-density lipoprotein cholesterol <40 mg/dL in men or <50 mg/dL in women; (4) blood pressure: systolic ? 30 and diastolic ?85 mm of mercury or on antihypertensive medication; and (5) fasting glucose ?110 mg/dL. The risk ratios (RR) with 95% confidence interval (CI) were estimated using multivariate Poisson regression models. A total of 419 White and 180 Black individuals with a mean age of 36 years were followed for 6.9 years. The findings demonstrated that hs-CRP mediated the influence of depression symptoms on central obesity in White young adults. The adjusted RR for central obesity was 1.08 with 95% CI of 0.88–1.32, and the value for hs-CRP was 1.12 with 95% CI of 1.02–1.23. Although depression did not influence MetS in this study cohort, the complete mediator role of hs-CRP was established for central obesity, a component of MetS in White young adults.

Keywords: metabolic syndrome; central obesity; depression; high sensitivity C-reactive protein; intracellular adhesion molecule-1; Bogalusa heart study (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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