NeuroSmog: Determining the Impact of Air Pollution on the Developing Brain: Project Protocol

Iana Markevych, Natasza Orlov, James Grellier, Katarzyna Kaczmarek-Majer, Małgorzata Lipowska, Katarzyna Sitnik-Warchulska, Yarema Mysak, Clemens Baumbach, Maja Wierzba-Łukaszyk, Munawar Hussain Soomro, Mikołaj Compa, Bernadetta Izydorczyk, Krzysztof Skotak, Anna Degórska, Jakub Bratkowski, Bartosz Kossowski, Aleksandra Domagalik and Marcin Szwed
Additional contact information
Iana Markevych: Institute of Psychology, Jagiellonian University, Ingardena 6, 30-060 Krakow, Poland
Natasza Orlov: Institute of Psychology, Jagiellonian University, Ingardena 6, 30-060 Krakow, Poland
James Grellier: Institute of Psychology, Jagiellonian University, Ingardena 6, 30-060 Krakow, Poland
Katarzyna Kaczmarek-Majer: Institute of Environmental Protection-National Research Institute, Krucza 5/11d, 00-548 Warsaw, Poland
Małgorzata Lipowska: Faculty of Management and Social Communication, Institute of Applied Psychology, Jagiellonian University, Łojasiewicza 4, 30-348 Krakow, Poland
Katarzyna Sitnik-Warchulska: Faculty of Management and Social Communication, Institute of Applied Psychology, Jagiellonian University, Łojasiewicza 4, 30-348 Krakow, Poland
Yarema Mysak: Institute of Psychology, Jagiellonian University, Ingardena 6, 30-060 Krakow, Poland
Clemens Baumbach: Institute of Psychology, Jagiellonian University, Ingardena 6, 30-060 Krakow, Poland
Maja Wierzba-Łukaszyk: Institute of Psychology, Jagiellonian University, Ingardena 6, 30-060 Krakow, Poland
Munawar Hussain Soomro: Institute of Psychology, Jagiellonian University, Ingardena 6, 30-060 Krakow, Poland
Mikołaj Compa: Institute of Psychology, Jagiellonian University, Ingardena 6, 30-060 Krakow, Poland
Bernadetta Izydorczyk: Institute of Psychology, Jagiellonian University, Ingardena 6, 30-060 Krakow, Poland
Krzysztof Skotak: Institute of Environmental Protection-National Research Institute, Krucza 5/11d, 00-548 Warsaw, Poland
Anna Degórska: Institute of Environmental Protection-National Research Institute, Krucza 5/11d, 00-548 Warsaw, Poland
Jakub Bratkowski: Institute of Environmental Protection-National Research Institute, Krucza 5/11d, 00-548 Warsaw, Poland
Bartosz Kossowski: Laboratory of Brain Imaging, Nencki Institute for Experimental Biology, Pasteur 3, 02-093 Warsaw, Poland
Aleksandra Domagalik: Brain Imaging Core Facility, Małopolska Centre of Biotechnology, Jagiellonian University, Gronostajowa 7A, 30-387 Krakow, Poland
Marcin Szwed: Institute of Psychology, Jagiellonian University, Ingardena 6, 30-060 Krakow, Poland

IJERPH, 2021, vol. 19, issue 1, 1-19

Abstract: Exposure to airborne particulate matter (PM) may affect neurodevelopmental outcomes in children. The mechanisms underlying these relationships are not currently known. We aim to assess whether PM affects the developing brains of schoolchildren in Poland, a country characterized by high levels of PM pollution. Children aged from 10 to 13 years ( n = 800) are recruited to participate in this case–control study. Cases (children with attention deficit hyperactivity disorder (ADHD)) are being recruited by field psychologists. Population-based controls are being sampled from schools. The study area comprises 18 towns in southern Poland characterized by wide-ranging levels of PM. Comprehensive psychological assessments are conducted to assess cognitive and social functioning. Participants undergo structural, diffusion-weighted, task, and resting-state magnetic resonance imaging (MRI). PM concentrations are estimated using land use regression models, incorporating information from air monitoring networks, dispersion models, and characteristics of roads and other land cover types. The estimated concentrations will be assigned to the prenatal and postnatal residential and preschool/school addresses of the study participants. We will assess whether long-term exposure to PM affects brain function, structure, and connectivity in healthy children and in those diagnosed with ADHD. This study will provide novel, in-depth understanding of the neurodevelopmental effects of PM pollution.

Keywords: PM 2.5; PM 10; children; neuroimaging; cognitive functioning; social functioning; epidemiology; Poland; air pollution; case–control study (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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