TUBE Project: Transport-Derived Ultrafines and the Brain Effects

Maria-Viola Martikainen, Päivi Aakko-Saksa, Lenie van den Broek, Flemming R. Cassee, Roxana O. Carare, Sweelin Chew, Andras Dinnyes, Rosalba Giugno, Katja M. Kanninen, Tarja Malm, Ala Muala, Maiken Nedergaard, Anna Oudin, Pedro Oyola, Tobias V. Pfeiffer, Topi Rönkkö, Sanna Saarikoski, Thomas Sandström, Roel P. F. Schins, Jan Topinka, Mo Yang, Xiaowen Zeng, Remco H. S. Westerink and Pasi I. Jalava
Additional contact information
Maria-Viola Martikainen: Department of Environmental and Biological Sciences, University of Eastern Finland, 70210 Kuopio, Finland
Päivi Aakko-Saksa: VTT Technical Research Centre of Finland Ltd., 02044 Espoo, Finland
Lenie van den Broek: Mimetas BV, 2312 BZ Oegstgeest, The Netherlands
Flemming R. Cassee: Centre for Sustainability, Environment and Health, National Institute for Public Health and the Environment (RIVM), 3721 MA Bilthoven, The Netherlands
Roxana O. Carare: Faculty of Medicine, University of Southampton, Southampton SO17 1BJ, UK
Sweelin Chew: A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70211 Kuopio, Finland
Andras Dinnyes: Biotalentum Ltd., 2100 Godollo, Hungary
Rosalba Giugno: Computer Science Department, University of Verona, 37129 Verona, Italy
Katja M. Kanninen: A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70211 Kuopio, Finland
Tarja Malm: A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, 70211 Kuopio, Finland
Ala Muala: Department of Public Health and Clinical Medicine, Division of Medicine/Respiratory Medicine, Umeå University, 901 87 Umea, Sweden
Maiken Nedergaard: Center for Translational Neuromedicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark
Anna Oudin: Department of Public Health and Clinical Medicine, Division of Medicine/Respiratory Medicine, Umeå University, 901 87 Umea, Sweden
Pedro Oyola: Centro Mario Molina Chile, Strategic Studies Department, Santiago 602, Chile
Tobias V. Pfeiffer: VSParticle B.V., 2629 JD Delft, The Netherlands
Topi Rönkkö: Aerosol Physics Laboratory, Physics Unit, Faculty of Engineering and Natural Sciences, Tampere University, 33720 Tampere, Finland
Sanna Saarikoski: Atmospheric Composition Research, Finnish Meteorological Institute, 00101 Helsinki, Finland
Thomas Sandström: Department of Public Health and Clinical Medicine, Division of Medicine/Respiratory Medicine, Umeå University, 901 87 Umea, Sweden
Roel P. F. Schins: IUF—Leibniz Research Institute for Environmental Medicine, 40225 Dusseldorf, Germany
Jan Topinka: Department of Genetic Toxicology and Epigenetics, Institute of Experimental Medicine of the CAS, Videnska 1083, 142 20 Prague, Czech Republic
Mo Yang: Department of Environmental and Biological Sciences, University of Eastern Finland, 70210 Kuopio, Finland
Xiaowen Zeng: Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China
Remco H. S. Westerink: Institute for Risk Assessment Sciences (IRAS), Utrecht University, 3508 TD Utrecht, The Netherlands
Pasi I. Jalava: Department of Environmental and Biological Sciences, University of Eastern Finland, 70210 Kuopio, Finland

IJERPH, 2021, vol. 19, issue 1, 1-14

Abstract: The adverse effects of air pollutants on the respiratory and cardiovascular systems are unquestionable. However, in recent years, indications of effects beyond these organ systems have become more evident. Traffic-related air pollution has been linked with neurological diseases, exacerbated cognitive dysfunction, and Alzheimer’s disease. However, the exact air pollutant compositions and exposure scenarios leading to these adverse health effects are not known. Although several components of air pollution may be at play, recent experimental studies point to a key role of ultrafine particles (UFPs). While the importance of UFPs has been recognized, almost nothing is known about the smallest fraction of UFPs, and only >23 nm emissions are regulated in the EU. Moreover, the role of the semivolatile fraction of the emissions has been neglected. The Transport-Derived Ultrafines and the Brain Effects (TUBE) project will increase knowledge on harmful ultrafine air pollutants, as well as semivolatile compounds related to adverse health effects. By including all the major current combustion and emission control technologies, the TUBE project aims to provide new information on the adverse health effects of current traffic, as well as information for decision makers to develop more effective emission legislation. Most importantly, the TUBE project will include adverse health effects beyond the respiratory system; TUBE will assess how air pollution affects the brain and how air pollution particles might be removed from the brain. The purpose of this report is to describe the TUBE project, its background, and its goals.

Keywords: air pollution; brain; particulate matter; UFP; toxicology; CNS; traffic (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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