Demographic and Clinical Factors Associated with Reactivity of Anti-SARS-CoV-2 Antibodies in Serbian Convalescent Plasma Donors

Jasmina Grujić, Nevenka Bujandrić, Zorana Budakov-Obradović, Vladimir Dolinaj, Damir Bogdan, Nebojša Savić, Alejandro Cabezas-Cruz, Dragana Mijatović, Verica Simin, Nikola Anđelić and Pavle Banović
Additional contact information
Jasmina Grujić: Blood Transfusion Institute Vojvodina, 21000 Novi Sad, Serbia
Nevenka Bujandrić: Blood Transfusion Institute Vojvodina, 21000 Novi Sad, Serbia
Zorana Budakov-Obradović: Blood Transfusion Institute Vojvodina, 21000 Novi Sad, Serbia
Vladimir Dolinaj: Faculty of Medicine in Novi Sad, University of Novi Sad, 21000 Novi Sad, Serbia
Damir Bogdan: Social Sciences and Computing, University of Belgrade, 11000 Belgrade, Serbia
Nebojša Savić: Transfusion Medicine Department, Clinic for Vascular and Endovascular Surgery, Clinical Centre of Serbia, 11000 Belgrade, Serbia
Alejandro Cabezas-Cruz: Anses, INRAE, Ecole Nationale Vétérinaire d’Alfort, UMR BIPAR, Laboratoire de Santé Animale, F-94700 Maisons-Alfort, France
Dragana Mijatović: Department of Prevention of Rabies and Other Infectious Diseases, Pasteur Institute Novi Sad, 21000 Novi Sad, Serbia
Verica Simin: Department of Microbiology, Pasteur Institute Novi Sad, 21000 Novi Sad, Serbia
Nikola Anđelić: Faculty of Medicine in Novi Sad, University of Novi Sad, 21000 Novi Sad, Serbia
Pavle Banović: Department of Prevention of Rabies and Other Infectious Diseases, Pasteur Institute Novi Sad, 21000 Novi Sad, Serbia

IJERPH, 2021, vol. 19, issue 1, 1-14

Abstract: Passive immunotherapy with convalescent COVID-19 plasma (CCP) is used as a therapeutic procedure in many countries, including Serbia. In this study, we analyzed the association between demographic factors, COVID-19 severity and the reactivity of anti-SARS-CoV-2 antibodies (Abs) in Serbian CCP donors. Individuals ( n = 468) recovered from confirmed SARS-CoV-2 infection, and who were willing to donate their plasma for passive immunization of COVID-19 patients were enrolled in the study. Plasma samples were tested for the presence of IgG reactive to SARS-CoV-2 spike glycoprotein (S1) and nucleocapsid antigens. Individuals were characterized according to age, gender, comorbidities, COVID-19 severity, ABO blood type and RhD factor. Total of 420 candidates (420/468; 89.74%) reached the levels of anti-SARS-CoV-2 IgG that qualified them for inclusion in CCP donation program. Further statistical analysis showed that male individuals ( p = 0.034), older age groups ( p < 0.001), existence of hypertension ( p = 0.008), and severe COVID-19 ( p = 0.000) are linked with higher levels of anti-SARS-CoV-2 Abs. These findings will guide the selection of CCP donors in Serbia. Further studies need to be conducted to assess the neutralization potency and clinical efficiency of CCP collected from Serbian donors with high anti-SARS-CoV-2 IgG reactivity.

Keywords: SARS-CoV-2; COVID-19; convalescent plasma; Serbia; donors; therapy (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2021
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