The Influence of FTO, FABP2, LEP, LEPR, and MC4R Genes on Obesity Parameters in Physically Active Caucasian Men

Ewelina Maculewicz, Agata Leońska-Duniec, Andrzej Mastalerz, Ewa Szarska, Aleksandra Garbacz, Tomasz Lepionka, Roman Łakomy, Anna Anyżewska and Jerzy Bertrandt
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Ewelina Maculewicz: Faculty of Physical Education, Jozef Pilsudski University of Physical Education in Warsaw, 00-809 Warsaw, Poland
Agata Leońska-Duniec: Faculty of Physical Education, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland
Andrzej Mastalerz: Faculty of Physical Education, Jozef Pilsudski University of Physical Education in Warsaw, 00-809 Warsaw, Poland
Ewa Szarska: Military Institute of Hygiene and Epidemiology, 01-163 Warsaw, Poland
Aleksandra Garbacz: Institute of Animal Sciences, Faculty of Animal Breeding, Bioengineering and Conservation, Warsaw University of Life Sciences—SGGW, 02-787 Warsaw, Poland
Tomasz Lepionka: Military Institute of Hygiene and Epidemiology, 01-163 Warsaw, Poland
Roman Łakomy: Military Institute of Hygiene and Epidemiology, 01-163 Warsaw, Poland
Anna Anyżewska: University of Economics and Human Sciences in Warsaw, Okopowa 59, 01-043 Warsaw, Poland
Jerzy Bertrandt: Faculty of Health Sciences, Pope John Paul II State School of Higher Education in Biala Podlaska, 21-500 Biala Podlaska, Poland

IJERPH, 2022, vol. 19, issue 10, 1-11

Abstract: Obesity is a complex multifactorial abnormality that has a well-confirmed genetic basis. However, the problem still lies in identifying the polymorphisms linked to body mass and composition. Therefore, this study aimed to analyze associations between FTO (rs9939609), FABP2 (rs1799883), and LEP (rs2167270), LEPR (rs1137101), and MC4R (rs17782313) polymorphisms and obesity-related parameters. Unrelated Caucasian males ( n = 165) were recruited. All participants had similar physical activity levels. The participants were divided into two groups depending on their body mass index (BMI) and fat mass index (FMI). All samples were genotyped using real-time polymerase chain reaction (real-time PCR). When tested individually, only one statistically significant result was found. The FTO A/T polymorphism was significantly associated with FMI ( p = 0.01). The chance of having increased FMI was >2-fold higher for the FTO A allele carriers ( p < 0.01). Gene–gene interaction analyses showed the additional influence of all investigated genes on BMI and FMI. In summary, it was demonstrated that harboring the FTO A allele might be a risk factor for elevated fat mass. Additionally, this study confirmed that all five polymorphisms are involved in the development of common obesity in the studied population and the genetic risk of obesity is linked to the accumulation of numerous variants.

Keywords: genes; SNPs; obesity-related traits; obesity risk; physical activity; Caucasian men (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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