Paroxysmal and Non-Paroxysmal Atrial Fibrillation in Middle Eastern Patients: Clinical Features and the Use of Medications. Analysis of the Jordan Atrial Fibrillation (JoFib) Study

Hanna Al-Makhamreh, Nasr Alrabadi, Lubna Haikal, Mohammad Krishan, Noor Al-Badaineh, Osama Odeh, Tawfiq Barqawi, Mohammed Nawaiseh, Ala Shaban, Basil Abdin, Lama Khamies and Ayman Hammoudeh
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Hanna Al-Makhamreh: Department of Cardiology, School of Medicine, University of Jordan, Amman 11972, Jordan
Nasr Alrabadi: Department of Pharmacology, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan
Lubna Haikal: School of Medicine, University of Jordan, Amman 11972, Jordan
Mohammad Krishan: School of Medicine, University of Jordan, Amman 11972, Jordan
Noor Al-Badaineh: School of Medicine, University of Jordan, Amman 11972, Jordan
Osama Odeh: School of Medicine, University of Jordan, Amman 11972, Jordan
Tawfiq Barqawi: School of Medicine, University of Jordan, Amman 11972, Jordan
Mohammed Nawaiseh: King Hussein Medical Center, Royal Medical Services, Amman 11855, Jordan
Ala Shaban: King Hussein Cancer Center, Amman 11941, Jordan
Basil Abdin: School of Medicine, University of Jordan, Amman 11972, Jordan
Lama Khamies: Department of Pharmacology, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan
Ayman Hammoudeh: Department of Cardiology, Istishari Hospital, Amman 11184, Jordan

IJERPH, 2022, vol. 19, issue 10, 1-11

Abstract: (1) Background: Atrial fibrillation (AF) is the most common arrhythmia causing an increased risk of mortality and morbidity. It is classified into paroxysmal and non-paroxysmal AF depending on the duration and frequency of the episodes. (2) Aims: Our goal was to investigate and compare the clinical profiles, risk of co-morbidities, the use of oral anticoagulation, and outcomes of patients with paroxysmal and non-paroxysmal AF in inpatient and outpatient settings. (3) Methods: Data were extracted from 28 different hospitals and centers in Jordan with a total of 2160 patients enrolled in the study using an observational non-interventional study model. The clinical features and the use of oral anticoagulants were compared in patients with paroxysmal and non-paroxysmal AF. (4) Results: Paroxysmal AF was documented in 35.6% (769) of the patients and non-paroxysmal types in 63.9% (1380); in addition, the type of AF was unknown in 11 (0.5%) patients. Our results showed that non-paroxysmal AF patients tend to be older with more co-morbidities and higher CHA2DS2-VASC and HAS-BLED scores. They also have higher rates of hypertension and diabetes. Anticoagulant, antiarrhythmic, and diuretic agents, overall, were used more in non-paroxysmal AF than paroxysmal AF. Hospital admissions were also more frequent in non-paroxysmal AF due to various factors, some of which are heart failure, bleeding risk, and COPD. (5) Conclusions: Non-paroxysmal AF is more common among Jordanian AF patients. The prevalence of comorbidities and the use of different types of therapies, especially anticoagulants, were higher in these patients.

Keywords: atrial fibrillation (AF); paroxysmal; non-paroxysmal; anticoagulants; arrhythmias (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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