Relationship between Exercise Intensity and IL-6 Increase during an 80 km Long-Distance Running Race

Romain Jouffroy, Dany Anglicheau, Nicolas Mansencal, Jean François Toussaint and Juliana Antero
Additional contact information
Romain Jouffroy: Intensive Care Unit, Ambroise Paré Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), 92100 Boulogne-Billancourt, France
Dany Anglicheau: Necker-Enfants Malades Institute, French National Institute of Health and Medical Research U1151, 75015 Paris, France
Nicolas Mansencal: INSERM U-1018, Centre de Recherche en Epidémiologie et Santé des Populations, Paris Saclay University, 94800 Paris, France
Jean François Toussaint: IRMES—Institute for Research in Medicine and Epidemiology of Sport, INSEP, 75012 Paris, France
Juliana Antero: IRMES—Institute for Research in Medicine and Epidemiology of Sport, INSEP, 75012 Paris, France

IJERPH, 2022, vol. 19, issue 11, 1-7

Abstract: Background : IL-6 plasma concentration (IL-6PC) reflects the systemic inflammation related to exercise intensity level. This study aims to describe the IL-6PC kinetics during a long-distance running race. IL-6PC was measured in 20 male runners before (0 km), at each refreshment point (at 21 and 53 km, i.e., k 21 and k 53 , respectively) and at the end of an 80 km long-distance run (k 80 ). Methods : IL-6PC variations (absolute and relative values in each of the three sections (S)) were calculated over S1 (0_k 21 ), S2 (k 21 _k 53 ) and S3 (k 53 _k 80 ) and compared with the exercise intensity (duration*race speed) within each section. Results : The mean IL-6PC increased during the run: 2.1 ± 0.6 ng.L −1 at 0 km, 21.0 ± 11.3 ng.L −1 at k 21 , 38.9 ± 13.0 ng.L −1 at k 53 and 49.8 ± 11.9 ng.L −1 at k 80 . Exercise intensity increased between S1 (24.2 ± 0.5) and S2 (51.9 ± 3.2) ( p = 0.04) but not between S2 and S3 (67.4 ± 4.5) ( p = 0.69). IL-6PC variation was associated with exercise intensity within S1 ( p = 0.03) and S2 ( p = 2 × 10 −3 ) and showed at least a trend within S3 ( p = 0.06). Conclusions : IL-6PC increases that occur during the early stages of a long-distance run are associated with the running intensity, and then IL-6PC remain stable after the reduction in intensity related to the decrease in running speed.

Keywords: running; long-distance run; exercise; intensity; interleukin 6 (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/19/11/6368/pdf (application/pdf)
https://www.mdpi.com/1660-4601/19/11/6368/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:19:y:2022:i:11:p:6368-:d:822630

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().