Precision Behavioral Management (PBM) and Cognitive Control as a Potential Therapeutic and Prophylactic Modality for Reward Deficiency Syndrome (RDS): Is There Enough Evidence?

Margaret A. Madigan, Ashim Gupta, Abdalla Bowirrat, David Baron, Rajendra D. Badgaiyan, Igor Elman, Catherine A. Dennen, Eric R. Braverman, Mark S. Gold and Kenneth Blum
Additional contact information
Margaret A. Madigan: The Kenneth Blum Behavioral & Neurogenetic Institute, LLC., Austin, TX 78701, USA
Ashim Gupta: Future Biologics, Lawrenceville, GA 30043, USA
Abdalla Bowirrat: Department of Molecular Biology, Adelson School of Medicine, Ariel University, Ariel 40700, Israel
David Baron: Center for Psychiatry, Medicine, & Primary Care (Office of Provost), Division of Addiction Research & Education, Western University Health Sciences, Pomona, CA 91766, USA
Rajendra D. Badgaiyan: Department of Psychiatry, South Texas Veteran Health Care System, Audie L. Murphy Memorial VA Hospital, Long School of Medicine, University of Texas Medical Center, San Antonio, TX 78229, USA
Igor Elman: Center for Pain and the Brain (P.A.I.N Group), Department of Anesthesiology, Critical Care & Pain Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA
Catherine A. Dennen: The Kenneth Blum Behavioral & Neurogenetic Institute, LLC., Austin, TX 78701, USA
Eric R. Braverman: The Kenneth Blum Behavioral & Neurogenetic Institute, LLC., Austin, TX 78701, USA
Mark S. Gold: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA
Kenneth Blum: The Kenneth Blum Behavioral & Neurogenetic Institute, LLC., Austin, TX 78701, USA

IJERPH, 2022, vol. 19, issue 11, 1-15

Abstract: This brief commentary aims to provide an overview of the available and relatively new precision management of reward deficiencies manifested as substance and behavioral disorders. Current and future advances, concepts, and the substantial evidential basis of this potential therapeutic and prophylactic treatment modality are presented. Precision Behavioral Management (PBM), conceptualized initially as Precision Addiction Management (PAM), certainly deserves consideration as an important modality for the treatment of impaired cognitive control in reward processing as manifested in people with neurobiologically expressed Reward Deficiency Syndrome (RDS).

Keywords: dopamine; hypodopaminergia; Genetic Addiction Risk Severity (GARS) test; pro-dopamine regulation (KB220); Restoregen ® (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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