The Effect of Chronic Immunosuppressive Regimens Treatment on Aortal Media Morphology and the Balance between Matrix Metalloproteinases (mmp-2 and mmp-9) and Their Inhibitors in the Abdominal Aorta of Rats

Anna Surówka, Kamila Szumilas, Aleksandra Wilk, Kamila Misiakiewicz-Has, Kazimierz Ciechanowski and Karolina Kędzierska-Kapuza
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Anna Surówka: Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, 70-111 Szczecin, Poland
Kamila Szumilas: Department of Physiology, Pomeranian Medical University, 70-111 Szczecin, Poland
Aleksandra Wilk: Department of Histology and Embryology, Pomeranian Medical University, 70-111 Szczecin, Poland
Kamila Misiakiewicz-Has: Department of Histology and Embryology, Pomeranian Medical University, 70-111 Szczecin, Poland
Kazimierz Ciechanowski: Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, 70-111 Szczecin, Poland
Karolina Kędzierska-Kapuza: Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, 70-111 Szczecin, Poland

IJERPH, 2022, vol. 19, issue 11, 1-16

Abstract: Immunosuppressive drugs are widely and chronically used to avoid graft rejection in transplant recipients. However, they are also known to have organotoxic effects and can exert numerous side effects. The aim of this study was to assess whether the chronic treatment of rats with the most commonly used clinical immunosuppressive regimens in organ recipients had an effect on the morphology and function of the aorta. The rats were divided into five groups and each group was chronically treated with different sets of three immunosuppressive drugs (TRG, CRG, MRG, CMG, TMG) for 6 months. The changes were most profound in calcineurin inhibitor-based protocols. TMG protocol treatment was characterized by the most numerous alterations such as morphological changes, changes in the thickness of the tunic media, wider distances between elastic lamellae, an increase in the number of vSMCs and changes in collagen deposition. We concluded that the morphological changes were connected with MMP-2 and MMP-9/TIMP-2 and TIMP-1 imbalances, which was also determined and noticed.

Keywords: immunosuppressive drugs; abdominal aorta; aortal media; metalloproteinases; metalloproteinase inhibitors; morphology; morphometry (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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