Level of Serum Fetuin-A Correlates with Heart Rate in Obstructive Sleep Apnea Patients without Metabolic and Cardiovascular Comorbidities

Elżbieta Reichert, Jerzy Mosiewicz, Wojciech Myśliński, Andrzej Jaroszyński, Agata Stanek, Klaudia Brożyna-Tkaczyk and Barbara Madejska-Mosiewicz
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Elżbieta Reichert: Individual Specialist Medical Practice, Włostowicka 293 C St., 24-100 Puławy, Poland
Jerzy Mosiewicz: Department of Internal Diseases, Medical University of Lublin, Staszica 16 St., 20-081 Lublin, Poland
Wojciech Myśliński: Department of Internal Diseases, Medical University of Lublin, Staszica 16 St., 20-081 Lublin, Poland
Andrzej Jaroszyński: Collegium Medicum, Jan Kochanowski University in Kielce, 23-517 Kielce, Poland
Agata Stanek: Department and Clinic of Internal Medicine, Angiology and Physical Medicine, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Batorego 15 St., 41-902 Bytom, Poland
Klaudia Brożyna-Tkaczyk: Department of Internal Diseases, 1st Public University Hospital No. 1 in Lublin, Staszica 16 St., 20-081 Lublin, Poland
Barbara Madejska-Mosiewicz: Department of Internal Diseases, 1st Public University Hospital No. 1 in Lublin, Staszica 16 St., 20-081 Lublin, Poland

IJERPH, 2022, vol. 19, issue 11, 1-11

Abstract: Obstructive sleep apnea (OSA) is the most common type of sleep-induced breathing disorder in the adult population and significantly affects the condition of the cardiovascular system. Fetuin-A (Fet-A) is a hepato- and adipokine, which prevents vessel calcification, and its level correlates with atherogenesis and metabolic disorders. The associations of cardiovascular diseases (CVD) both with OSA, which increases CVD risk, and Fet-A, which prevents CVD, justify the question of their mutual interactions in patients with OSA. Therefore, we sought to analyze Fet-A as an early biomarker of CVD risk in OSA patients without metabolic and cardiovascular comorbidities except for properly controlled arterial hypertension. We have found that in these patients, OSA does not appear to directly affect Fet-A levels. However, high Fet-A levels were more common in the group of patients with OSA, and the hypopnea index was significantly higher among subjects with the highest Fet-A levels. The level of Fet-A in OSA patients positively correlates with pulse rate, and it does not correlate with pulse pressure in this group unlike in the control group, where such a relationship exists. To our best knowledge, this is the first study to analyze this relationship in OSA patients without any significant cardiovascular comorbidities.

Keywords: obstructive sleep apnea; Fetuin-A; polygraphy; cardiovascular diseases (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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