Association of Hand Grip Strength with Mild Cognitive Impairment in Middle-Aged and Older People in Guangzhou Biobank Cohort Study

Ya-Li Jin, Lin Xu, Chao-Qiang Jiang, Wei-Sen Zhang, Jing Pan, Feng Zhu, Tong Zhu, Graham Neil Thomas and Tai-Hing Lam
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Ya-Li Jin: Guangzhou Twelfth People’s Hospital, Guangzhou 510620, China
Lin Xu: School of Public Health, Sun Yat-sen University, Guangzhou 510080, China
Chao-Qiang Jiang: Guangzhou Twelfth People’s Hospital, Guangzhou 510620, China
Wei-Sen Zhang: Guangzhou Twelfth People’s Hospital, Guangzhou 510620, China
Jing Pan: Guangzhou Twelfth People’s Hospital, Guangzhou 510620, China
Feng Zhu: Guangzhou Twelfth People’s Hospital, Guangzhou 510620, China
Tong Zhu: Guangzhou Twelfth People’s Hospital, Guangzhou 510620, China
Graham Neil Thomas: Institute of Applied Health Research, University of Birmingham, Birmingham B15 2TT, UK
Tai-Hing Lam: School of Public Health, The University of Hong Kong, Hong Kong

IJERPH, 2022, vol. 19, issue 11, 1-12

Abstract: Background: Lower hand grip strength has been linked to cognitive impairment, but studies in older Chinese are limited. We examined the association of hand grip strength with cognitive function in a large sample of older Chinese. Methods: 6806 participants aged 50+ years from the Guangzhou Biobank Cohort Study (GBCS) were included. Relative grip strength was calculated by absolute handgrip strength divided by the body mass index (BMI). Cognitive function was assessed using the Delayed Word Recall Test (DWRT, from 0 to 10) and the Mini Mental State Examination (MMSE, from 0 to 30), with higher scores indicating better cognition. Results: After adjusting for multiple potential confounders, lower absolute grip strength and relative grip strength were significantly associated with lower DWRT (all p < 0.05) in all participants. No significant interaction effects between sex and handgrip strength on cognitive impairment were found ( p from 0.27 to 0.87). No significant association between handgrip strength and total MMSE scores was found in the total sample or by sex ( p from 0.06 to 0.50). Regarding the individual components of MMSE, lower absolute and relative grip strength were significantly associated with lower scores of the recall memory performance in all participants ( p from 0.003 to 0.04). Conclusion: We have shown for the first time a positive association of grip strength with recall memory performance, but not general cognitive function in older people, which warrants further investigation.

Keywords: hand grip strength; mild cognitive impairment; Delayed Word Recall Test (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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