Effects of Commercial Probiotics on Colonic Sensitivity after Acute Mucosal Irritation

Laura López-Gómez, Jaime Antón, Yolanda López-Tofiño, Bianca Pomana, José A. Uranga and Raquel Abalo
Additional contact information
Laura López-Gómez: Department of Basic Health Sciences, University Rey Juan Carlos (URJC), 28922 Alcorcón, Spain
Jaime Antón: Department of Basic Health Sciences, University Rey Juan Carlos (URJC), 28922 Alcorcón, Spain
Yolanda López-Tofiño: Department of Basic Health Sciences, University Rey Juan Carlos (URJC), 28922 Alcorcón, Spain
Bianca Pomana: Department of Basic Health Sciences, University Rey Juan Carlos (URJC), 28922 Alcorcón, Spain
José A. Uranga: Department of Basic Health Sciences, University Rey Juan Carlos (URJC), 28922 Alcorcón, Spain
Raquel Abalo: Department of Basic Health Sciences, University Rey Juan Carlos (URJC), 28922 Alcorcón, Spain

IJERPH, 2022, vol. 19, issue 11, 1-22

Abstract: Gastrointestinal pathologies associated with abdominal pain, such as irritable bowel syndrome or inflammatory bowel disease, lack sufficiently effective treatments. In our study we have used a rat model of visceral pain (72 animals; n = 8–13 per experimental group) to analyze the consequences of intracolonic administration of the irritant acetic acid on visceral sensitivity, histology of the colonic wall, and inflammatory response. Moreover, we have studied the possible beneficial effects of a pretreatment with a commercial probiotic (Actimel ® ). Contrary to expectations, acetic acid application (7 cm proximal to the anus) decreased the nociceptive response to intracolonic mechanical stimulation, with a slight increase in the histological damage of colonic mucosa. The intensity of these changes depended on the concentration (4% or 0.6%) and the time of application (30 or 60 min). Pretreatment with probiotics (by daily gavage, for 1 week) normalized the values obtained in the visceral sensitivity test but revealed an increase in the number of macrophages. These results suggest a possible activation of inhibitory mechanisms early after colonic irritation, not previously described (which need further experimental confirmation), and the ability of probiotics to normalize the effects of acetic acid. In addition, pretreatment with probiotics has a direct effect on immune functions, stimulating macrophagic activity.

Keywords: animal model; inflammatory bowel disease; irritable bowel syndrome; probiotics; visceral pain (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/19/11/6485/pdf (application/pdf)
https://www.mdpi.com/1660-4601/19/11/6485/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:19:y:2022:i:11:p:6485-:d:824901

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().