Treatment Adherence and Health-Related Quality of Life in Patients with Hemophilia in Hong Kong

Yin Ting Cheung, Pok Hong Lam, Henry Hon Wai Lam, Chung-Tin Ma, Alex Wing Kwan Leung, Raymond Siu Ming Wong and Chi Kong Li
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Yin Ting Cheung: School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
Pok Hong Lam: Department of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
Henry Hon Wai Lam: Hong Kong Haemophilia Society, Hong Kong, China
Chung-Tin Ma: School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
Alex Wing Kwan Leung: Department of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
Raymond Siu Ming Wong: Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
Chi Kong Li: Department of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China

IJERPH, 2022, vol. 19, issue 11, 1-13

Abstract: Background: This study aims to identify factors affecting health-related quality of life (HRQoL) in Chinese patients with hemophilia in Hong Kong, and to examine the association between treatment adherence and HRQoL outcomes. Methods: Patients with hemophilia A or B from a non-governmental organization reported their HRQoL and treatment adherence to prophylactic therapy using validated tools. Univariate tests and multivariable regression analysis were used to compare differences in outcomes across clinically relevant subgroups. Results: Fifty-six patients were recruited (mean age 30.4 [17.4] years; majority hemophilia A: 75%; moderate-to-severe severity: 88%). Patients who received prophylactic treatment reported fewer work/school problems (25.8 [18.9] versus 51.5 [26.3]; p = 0.001) than those who received on-demand therapy. The multivariable model showed that older age ( B = 0.42, 95% CI = 0.093–0.75) and living in public housing ( B = 10.24, 95% CI = 0.70–19.77) were associated with worse HRQoL. Older age was associated with treatment non-adherence ( r = 0.66, p < 0.0001). Patients with poor adherence tended to report worse functioning in sports/leisure ( r = 0.31, p = 0.033). Conclusions: Our results suggest that patients who were older, had lower education attainment and received on-demand treatment had poorer perception of their health. Improving adherence may lead to better HRQoL. Future work includes evaluating the occupational needs prospectively in this population.

Keywords: hemophilia; quality of life; treatment adherence; supportive care; chronic illness (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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