Exercise and Reduced Nicotine Content Cigarettes in Adult Female Smokers: A Pilot Trial

Chaofan Li, Nengliang Yao, Stephanie L. Miller, Christopher Macpherson, Taryn Hassinger, Kaitlin Love and Steven K. Malin
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Chaofan Li: Centre for Health Management and Policy Research, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China
Nengliang Yao: Centre for Health Management and Policy Research, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China
Stephanie L. Miller: Department of Kinesiology, University of Virginia, Charlottesville, VA 22904, USA
Christopher Macpherson: Department of Kinesiology, University of Virginia, Charlottesville, VA 22904, USA
Taryn Hassinger: Department of Medicine, University of Virginia, Charlottesville, VA 22904, USA
Kaitlin Love: Division of Endocrinology and Metabolism, University of Virginia, Charlottesville, VA 22904, USA
Steven K. Malin: Department of Kinesiology, University of Virginia, Charlottesville, VA 22904, USA

IJERPH, 2022, vol. 19, issue 11, 1-11

Abstract: Background: Although Reduced Nicotine Cigarettes (RNC) are suggested to improve smoking cessation and cardiometabolic health in relation to cancer risk, the effectiveness of exercise training with RNC on smoking cessation and cardiometabolic health is unknown. Methods: Female smokers (N = 27) were randomized to: (1) usual nicotine cigarettes (i.e., control), (2) RNC or (3) RNC plus exercise treatment for 12 weeks. Smoking withdrawal symptoms (e.g., Wisconsin Smoking Withdrawal Scale) and cardiometabolic health (e.g., weight, VO 2 max, resting respiratory exchange ratio (RER), glucose, HOMA-IR) were examined before and after treatment. Results: Treatments had no differential effect on weight ( p = 0.80; partial η 2 = 0.29), VO 2 max ( p = 0.20, partial η 2 = 0.18), or total cholesterol/HDL ratios ( p = 0.59, partial η 2 = 0.06). However, RNC + Exercise tended to maintain RER (i.e., fat oxidation; p = 0.10, partial η 2 = 0.10) as well as insulin resistance ( p = 0.13, partial η 2 = 0.25) and cortisol compared ( p = 0.06, partial η 2 = 0.30) with control and RNC. Increased VO 2 max was also associated with lower nicotine dependence scores (r = −0.50, p < 0.05). Conclusion: In this pilot study, improved fitness was associated with lower nicotine dependence. Additional work is warranted to examine the effects of exercise in smokers as a tool to improving smoking cessation and lower disease risk.

Keywords: physical activity; smoking cessation; insulin resistance; obesity; cardiovascular disease (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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