Construct Validity and Responsiveness of the COVID-19 Yorkshire Rehabilitation Scale (C19-YRS) in a Cohort of Italian Hospitalized COVID-19 Patients

Sofia Straudi, Fabio Manfredini, Andrea Baroni, Giada Milani, Giulia Fregna, Nicola Schincaglia, Riccardo Androni, Antonella Occhi, Manoj Sivan and Nicola Lamberti
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Sofia Straudi: Department of Neuroscience and Rehabilitation, Ferrara University Hospital, 44124 Ferrara, Italy
Fabio Manfredini: Department of Neuroscience and Rehabilitation, Ferrara University Hospital, 44124 Ferrara, Italy
Andrea Baroni: Department of Neuroscience and Rehabilitation, Ferrara University Hospital, 44124 Ferrara, Italy
Giada Milani: Department of Neuroscience and Rehabilitation, Ferrara University Hospital, 44124 Ferrara, Italy
Giulia Fregna: Doctoral Program in Translational Neurosciences and Neurotechnologies, Ferrara University, 44121 Ferrara, Italy
Nicola Schincaglia: Department of Neuroscience and Rehabilitation, Ferrara University Hospital, 44124 Ferrara, Italy
Riccardo Androni: School of Physiotherapy, Ferrara University, 44121 Ferrara, Italy
Antonella Occhi: Department of Neuroscience and Rehabilitation, Ferrara University Hospital, 44124 Ferrara, Italy
Manoj Sivan: Academic Department of Rehabilitation Medicine, University of Leeds, D Floor, Martin Wing, Leeds General Infirmary, Leeds LS1 3EX, UK
Nicola Lamberti: Department of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy

IJERPH, 2022, vol. 19, issue 11, 1-12

Abstract: Post-COVID Syndrome (PCS) is characterized by physical, psychological and cognitive symptoms with a negative impact on daily activities. This study tested the responsiveness and construct validity of the original version of the COVID-19 Yorkshire Rehabilitation Scale (C19-YRS) in a cohort of Italian hospitalized COVID-19 patients. This longitudinal study involved 79 hospitalized COVID-19 patients with rehabilitation needs, assessed after 12 and 26 weeks post-infection. Functional and patient-reported outcome measures were correlated with 10 items of the C19-YRS to test the construct validity, whereas distribution-based methods were used for the responsiveness over time. After 12 weeks since infection, 88.5% of patients reported fatigue, 83.3% breathlessness, 69.4% anxiety, 55.6% depression, and 44.9% pain. Moreover, 84.6% experienced reduced mobility, 75.7% had difficulties with usual activities, and 47.4% with personal care. Single items for each symptom had significant correlation (rho 0.25–0.60) with well-established scales for these symptoms. At 26 weeks, except for anxiety, all the PCS symptoms were still present but significantly reduced. The C19-YRS had moderate responsiveness for the most represented deficit reported. The C19-YRS was a valuable patient-reported outcome for screening, assessing severity, and monitoring the persistence of symptoms after 12 and 26 weeks from SARS-CoV2 infection in a cohort of Italian hospitalized patients.

Keywords: Post-COVID Syndrome; outcome measures; rehabilitation; COVID-19 (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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