Association of Peripheral Arterial Occlusive Disease and Deep Venous Thrombosis with Risk of Consequent Sepsis Event: A Retrospective Population-Based Cohort Study

Bo-Yuan Wang, Ying-Hsiang Chou, Chi-Tzu Chung, Shun-Fa Yang, Shu-Ling Tzeng, Yu-Hsun Wang, Ming-Chih Chou, Chao-Bin Yeh and Chi-Ho Chan
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Bo-Yuan Wang: Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
Ying-Hsiang Chou: Department of Radiation Oncology, Chung Shan Medical University Hospital, Taichung 402, Taiwan
Chi-Tzu Chung: Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
Shun-Fa Yang: Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
Shu-Ling Tzeng: Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
Yu-Hsun Wang: Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan
Ming-Chih Chou: Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
Chao-Bin Yeh: Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
Chi-Ho Chan: Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan

IJERPH, 2022, vol. 19, issue 11, 1-11

Abstract: Peripheral artery occlusive disease (PAOD) and deep vein thrombosis (DVT) can cause a variety of acute and chronic vascular complications and put patients at risk of subsequent sepsis. This study aimed to determine whether DVT compared with PAOD patients would increase the risk of sepsis. This study recruited 43,535 patients newly diagnosed as having PAOD and 6932 patients who were newly diagnosed as having DVT from a population of 2 million patients from the Longitudinal Health Insurance Database. Propensity score matching (PSM) between the PAOD and DVT groups was performed for age, sex, comorbidities, and prior antibiotic administration. A total of 4383 patients with PAOD and 4383 patients with DVT were analyzed for risk of sepsis. The incidence density of sepsis per 1000 person years for patients with PAOD was 25.75 (95% CI = 23.90 to 27.74) and 35.61 (95% CI = 33.29 to 38.09) for patients with DVT. After age, sex, associated comorbidities, and antibiotic administration were adjusted for, the risk of sepsis for the DVT group was 1.46-fold (95% CI = 1.32–1.62) higher than that for the PAOD group. In conclusion, patients with DVT were associated with a higher risk of subsequent sepsis than patients with PAOD. Aging was another risk factor.

Keywords: peripheral arterial occlusive disease; deep vein thrombosis; sepsis; risk (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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