Thyroid Dysfunction and COVID-19: The Emerging Role of Selenium in This Intermingled Relationship

Francesca Gorini, Laura Sabatino, Alessio Coi, Giorgio Iervasi and Cristina Vassalle
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Francesca Gorini: Institute of Clinical Physiology, National Research Council, 56124 Pisa, Italy
Laura Sabatino: Institute of Clinical Physiology, National Research Council, 56124 Pisa, Italy
Alessio Coi: Institute of Clinical Physiology, National Research Council, 56124 Pisa, Italy
Giorgio Iervasi: Institute of Clinical Physiology, National Research Council, 56124 Pisa, Italy
Cristina Vassalle: Fondazione CNR-Regione Toscana Gabriele Monasterio, 56124 Pisa, Italy

IJERPH, 2022, vol. 19, issue 11, 1-24

Abstract: COVID-19 represents a worldwide public health emergency, and, beyond the respiratory symptoms characterizing the classic viral disease, growing evidence has highlighted a possible reciprocal relationship between SARS-CoV-2 infection and thyroid dysfunction. The updated data discussed in this review suggests a role of SARS-CoV-2 infection on the thyroid gland, with multiple thyroid pictures described. Conversely, no conclusion can be drawn on the association between pre-existing thyroid disease and increased risk of SARS-CoV-2 infection. In this scenario, selenium (Se), an essential trace element critical for thyroid function and known as an effective agent against viral infections, is emerging as a potential novel therapeutic option for the treatment of COVID-19. Large multicentre cohort studies are required to elucidate the mechanisms underlying thyroid dysfunction during or following recovery from COVID-19, including Se status. Meanwhile, clinical trials should be performed to evaluate whether adequate intake of Se can help address COVID-19 in Se-deficient patients, also avoiding thyroid complications that can contribute to worsening outcomes during infection.

Keywords: COVID-19; coronavirus; thyroid disease; thyroiditis; selenium (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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