Comparative Effectiveness of Various Eradication Regimens for Helicobacter Pylori Infection in the Northeastern Region of Poland

Justyna Wasielica-Berger, Patryk Gugnacki, Maryla Mlynarczyk, Pawel Rogalski, Agnieszka Swidnicka-Siergiejko, Stefania Antonowicz, Michalina Krzyzak, Dominik Maslach, Andrzej Dabrowski and Jaroslaw Daniluk
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Justyna Wasielica-Berger: Department of Gastroenterology and Internal Medicine, Medical University of Bialystok, 15-276 Bialystok, Poland
Patryk Gugnacki: Department of Oncology, Medical University of Bialystok, 15-025 Bialystok, Poland
Maryla Mlynarczyk: Department of Histology and Cytophysiology, Medical University of Bialystok, 15-025 Bialystok, Poland
Pawel Rogalski: Department of Gastroenterology and Internal Medicine, Medical University of Bialystok, 15-276 Bialystok, Poland
Agnieszka Swidnicka-Siergiejko: Department of Gastroenterology and Internal Medicine, Medical University of Bialystok, 15-276 Bialystok, Poland
Stefania Antonowicz: Department of Gastroenterology and Internal Medicine, Medical University of Bialystok, 15-276 Bialystok, Poland
Michalina Krzyzak: Department of Hygiene, Epidemiology and Ergonomics, Medical University of Bialystok, 15-022 Bialystok, Poland
Dominik Maslach: Department of Public Health, Medical University of Bialystok, 15-295 Bialystok, Poland
Andrzej Dabrowski: Department of Gastroenterology and Internal Medicine, Medical University of Bialystok, 15-276 Bialystok, Poland
Jaroslaw Daniluk: Department of Gastroenterology and Internal Medicine, Medical University of Bialystok, 15-276 Bialystok, Poland

IJERPH, 2022, vol. 19, issue 11, 1-12

Abstract: Purpose: Due to the lack of systematic data on antibiotic sensitivity, the treatment of the highly prevalent and pathogenic Helicobacter pylori ( H. pylori ) infection still poses a significant problem. Therefore, the aim of our study was to compare the efficacy of the three most commonly used anti- H. pylori therapies in northeastern Poland. Patients and Methods: This was a retrospective, single-center study performed on 289 outpatients with an H. pylori infection. Patients received one of the following three treatment regimens: (1) bismuth quadruple therapy (BQT) for 10 days, (2) metronidazole-based triple therapy (M-TT) for 10 or 14 days, and (3) levofloxacin-based triple therapy (L-TT) for 10 or 14 days. Results: BQT, M-TT, and L-TT accounted for 93.2% of prescribed anti- H. pylori therapies. The overall success rate for all treatment regimens was 84.1% (243/289). The effectiveness of first- and second-line therapy was similar and reached 83.8% and 86.2%, respectively. The efficacy of the individual treatment regimens was as follows: (1) BQT—89.4% (84/94), (2) M-TT—80.6% (112/139) and 78.8% (26/33) for 10 and 14 days, respectively, and (3) L-TT—84.6% (11/13) and 100% (10/10) for 10 and 14 days, respectively. The overall duration of treatment and type and dose of proton pump inhibitor (PPI) had no effect on the treatment efficacy. Conclusions: In the northeastern part of Poland, 10-day BQT and 10- or 14-day L-TT are effective treatment regimens for H. pylori eradication and have appear to be superior to M-TT. Practitioners in our clinic followed mostly local anti- H. pylori therapy guidelines.

Keywords: bismuth-containing quadruple therapy; eradication; Helicobacter pylori; levofloxacin-based triple therapy; metronidazole-based triple therapy; Poland (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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