Positive Effect of Air Purifier Intervention on Baroreflex Sensitivity and Biomarkers of Oxidative Stress in Patients with Coronary Artery Disease: A Randomized Crossover Intervention Trial

Sang-Yong Eom, Aryun Kim, Ju-Hee Lee, Sang Min Kim, Sang-Yeub Lee, Kyung-Kuk Hwang, Hyun-Joung Lim, Myeong-Chan Cho, Yong-Dae Kim, Jang-Whan Bae, Jun Hyung Kim and Dae-In Lee
Additional contact information
Sang-Yong Eom: Department of Preventive Medicine, College of Medicine, Chungbuk National University, Cheongju 28644, Korea
Aryun Kim: Department of Neurology, Chungbuk National University Hospital, Cheongju 28644, Korea
Ju-Hee Lee: Department of Cardiology, Chungbuk National University Hospital, Cheongju 28644, Korea
Sang Min Kim: Department of Cardiology, Chungbuk National University Hospital, Cheongju 28644, Korea
Sang-Yeub Lee: Department of Cardiology, Chungbuk National University Hospital, Cheongju 28644, Korea
Kyung-Kuk Hwang: Department of Cardiology, Chungbuk National University Hospital, Cheongju 28644, Korea
Hyun-Joung Lim: Division of Allergy and Respiratory Disease Research, Korea National Institute of Health, Cheongju 28159, Korea
Myeong-Chan Cho: Department of Cardiology, Chungbuk National University Hospital, Cheongju 28644, Korea
Yong-Dae Kim: Department of Preventive Medicine, College of Medicine, Chungbuk National University, Cheongju 28644, Korea
Jang-Whan Bae: Department of Cardiology, Chungbuk National University Hospital, Cheongju 28644, Korea
Jun Hyung Kim: Department of Internal Medicine, College of Medicine, Chungnam National University, Daejeon 34134, Korea
Dae-In Lee: Department of Cardiology, Chungbuk National University Hospital, Cheongju 28644, Korea

IJERPH, 2022, vol. 19, issue 12, 1-10

Abstract: Exposure to fine particulate matter increases the risk of cardiovascular morbidity and mortality. Few studies have tested the beneficial effect of indoor air filtration intervention in patients with cardiovascular disease. The aim of this study is to investigate the effect of air filtration on mitigating cardiovascular health in patients with coronary artery disease. This randomized, double-blind, crossover study is conducted with 38 coronary artery disease patients. The intervention consists of the following three periods: two-week active and sham air filtration interventions, with a two-week washout period. The indoor PM 2.5 concentration is continuously monitored during the entire study period. We measure the blood pressure, heart rate variability, baroreflex sensitivity, autonomic function test results, and endothelial function. The two-week active air filtration intervention for two weeks reduces the average indoor concentration of PM 2.5 by 33.9%. The indoor PM 2.5 concentration is significantly correlated to cross-correlation baroreflex sensitivity. Active air filtration is significantly associated with a decrease in the indicator of oxidative stress represented as 8-hydroxy-2′-deoxyguanosine. This study shows that a short-term air filtration intervention improved baroreflex sensitivity and might reduce oxidative stress in coronary artery disease patients. These findings suggest that the use of an air purifier could mitigate the recurrence of cardiovascular disease events in patients with coronary artery disease.

Keywords: particulate matter; air purifier; baroreflex sensitivity; oxidative stress; coronary artery disease (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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