Occupational Low-Dose Radiation Affects the Expression of Immune Checkpoint of Medical Radiologists

Chen Wang, Changfu Hao, Kai Dai, Yuzheng Li, Jie Jiao, Zhuoya Niu, Xiao Xu, Xuedan Deng, Jing He and Wu Yao
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Chen Wang: Department of Occupational Health and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, China
Changfu Hao: Department of Occupational Health and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, China
Kai Dai: Department of Occupational Health and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, China
Yuzheng Li: Henan Institute of Occupational Medicine, Zhengzhou 450001, China
Jie Jiao: Henan Institute of Occupational Medicine, Zhengzhou 450001, China
Zhuoya Niu: Department of Occupational Health and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, China
Xiao Xu: Department of Occupational Health and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, China
Xuedan Deng: Department of Occupational Health and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, China
Jing He: Department of Occupational Health and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, China
Wu Yao: Department of Occupational Health and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, China

IJERPH, 2022, vol. 19, issue 12, 1-14

Abstract: The purpose of this study was to investigate the expression of immune checkpoint cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and T cell immunoglobulin and mucin domain 3 (TIM-3) in the peripheral blood T lymphocytes of medical radiologists. The study incorporated 100 male medical radiologists and 107 male healthy controls. The expressions of CTLA-4 and TIM-3 among CD4+ and CD8+ lymphocytes were detected by flow cytometry. The expression levels of CTLA-4 and TIM-3 in the CD4+T cells of radiation workers were lower than those of healthy controls ( p < 0.05). Correlation analysis showed that the CD8+CTLA-4 expression level was significantly positively correlated with individual cumulative dose ( r s = 0.260, p = 0.001, <0.05), while the expression level of CD8+TIM-3 was negatively correlated ( r s = −0.180, p = 0.027, <0.05). Low-dose radiation exposure affects the expression of CTLA-4 and TIM-3 in human peripheral blood T lymphocytes. Future studies need to focus on exploring the mechanisms by which CTLA-4 and TIM-3 expression changes in response to low-dose radiation exposure.

Keywords: low-dose radiation; radiation workers; T lymphocytes; immune checkpoint; CTLA-4; TIM-3 (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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