Association between Gut Microbiota and Body Composition in Japanese General Population: A Focus on Gut Microbiota and Skeletal Muscle

Yoshikuni Sugimura, Akira Kanda, Kaori Sawada, Kyi Mar Wai, Asano Tanabu, Naoki Ozato, Tatsuyuki Midorikawa, Takayoshi Hisada, Shigeyuki Nakaji and Kazushige Ihara
Additional contact information
Yoshikuni Sugimura: Department of Innovation Center for Health Promotion, Graduate School of Medicine, Hirosaki University 5 Zaifu-cho, Hirosaki 036-8562, Japan
Akira Kanda: Department of Nutrition, Faculty of Health Sciences, Aomori University of Health and Welfare, 58-1 Mase, Hamadate, Aomori 030-8505, Japan
Kaori Sawada: Department of Social Medicine, Graduate School of Medicine, Hirosaki University 5 Zaifu-cho, Hirosaki 036-8562, Japan
Kyi Mar Wai: Department of Social Medicine, Graduate School of Medicine, Hirosaki University 5 Zaifu-cho, Hirosaki 036-8562, Japan
Asano Tanabu: Department of Social Medicine, Graduate School of Medicine, Hirosaki University 5 Zaifu-cho, Hirosaki 036-8562, Japan
Naoki Ozato: Health & Wellness Products Research Laboratories, Kao Corporation, 2-1-3 Bunka, Sumida-ku, Tokyo 131-8501, Japan
Tatsuyuki Midorikawa: Department of Social Medicine, Graduate School of Medicine, Hirosaki University 5 Zaifu-cho, Hirosaki 036-8562, Japan
Takayoshi Hisada: TechnoSuruga Laboratory Co., Ltd., 388-1 Nagasaki, Shimizu-ku, Shizuoka 424-0065, Japan
Shigeyuki Nakaji: Department of Innovation Center for Health Promotion, Graduate School of Medicine, Hirosaki University 5 Zaifu-cho, Hirosaki 036-8562, Japan
Kazushige Ihara: Department of Social Medicine, Graduate School of Medicine, Hirosaki University 5 Zaifu-cho, Hirosaki 036-8562, Japan

IJERPH, 2022, vol. 19, issue 12, 1-12

Abstract: This study aimed to investigate the gut microbial genera associated with skeletal muscle mass, using a large-scale survey from the standpoint of preventing sarcopenia. A total of 848 participants were included in the analysis. The mean (SD) ages of men ( n = 353) and women ( n = 495) were 50.0 (12.9) years and 50.8 (12.8) years, respectively. Body composition was assessed using appendicular skeletal muscle mass/body weight (ASM/BW), ASM, and BW. Additionally, the relationship between gut microbial genera and body composition was analyzed. The means (SD) of ASM/BW were 34.9 (2.4) % in men and 29.4 (2.9) % in women. Blautia and Bifidobacterium were positively associated with ASM/BW only in men ( Blautia : β = 0.0003, Bifidobacterium : β = 0.0001). However, Blautia was negatively associated with BW (β = −0.0017). Eisenbergiella was positively associated with ASM/BW (β = 0.0209) and negatively associated with BW (β = −0.0769) only in women. Our results indicate that Blautia , Bifidobacterium and Eisenbergiella , which are positively associated with ASM/BW, might help increase skeletal muscle mass. ASM/BW may clarify the relationship between gut microbiota and skeletal muscle mass without being affected by obesity or excess body fat mass.

Keywords: sarcopenia; gut microbiota; skeletal muscle mass; skeletal muscle mass index (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.mdpi.com/1660-4601/19/12/7464/pdf (application/pdf)
https://www.mdpi.com/1660-4601/19/12/7464/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:19:y:2022:i:12:p:7464-:d:841684

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().