Recent Insights into Particulate Matter (PM 2.5 )-Mediated Toxicity in Humans: An Overview

Prakash Thangavel, Duckshin Park and Young-Chul Lee
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Prakash Thangavel: Department of BioNano Technology, Gachon University, 1342 Seongnamdaero, Sujeong-gu, Seongnam-si 13120, Gyeonggi-do, Korea
Duckshin Park: Korea Railroad Research Institute (KRRI), 176 Cheoldobakmulkwan-ro, Uiwang-si 16105, Gyeonggi-do, Korea
Young-Chul Lee: Department of BioNano Technology, Gachon University, 1342 Seongnamdaero, Sujeong-gu, Seongnam-si 13120, Gyeonggi-do, Korea

IJERPH, 2022, vol. 19, issue 12, 1-22

Abstract: Several epidemiologic and toxicological studies have commonly viewed ambient fine particulate matter (PM 2.5 ), defined as particles having an aerodynamic diameter of less than 2.5 µm, as a significant potential danger to human health. PM 2.5 is mostly absorbed through the respiratory system, where it can infiltrate the lung alveoli and reach the bloodstream. In the respiratory system, reactive oxygen or nitrogen species (ROS, RNS) and oxidative stress stimulate the generation of mediators of pulmonary inflammation and begin or promote numerous illnesses. According to the most recent data, fine particulate matter, or PM 2.5 , is responsible for nearly 4 million deaths globally from cardiopulmonary illnesses such as heart disease, respiratory infections, chronic lung disease, cancers, preterm births, and other illnesses. There has been increased worry in recent years about the negative impacts of this worldwide danger. The causal associations between PM 2.5 and human health, the toxic effects and potential mechanisms of PM 2.5 , and molecular pathways have been described in this review.

Keywords: air pollution; particulate matter; PM 2.5; health effects; COVID; H1N1; SARS (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (9)

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