Pesticide Exposure in Relation to the Incidence of Abnormal Glucose Regulation: A Retrospective Cohort Study

Sung-Kyung Kim, Hyun-Jung Oh, Sung-Soo Oh and Sang-Baek Koh
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Sung-Kyung Kim: Department of Occupational and Environmental Medicine, Institute of Occupational and Environmental Medicine, Wonju College of Medicine, Yonsei University, Wonju 26426, Korea
Hyun-Jung Oh: Department of Occupational and Environmental Medicine, Institute of Occupational and Environmental Medicine, Wonju College of Medicine, Yonsei University, Wonju 26426, Korea
Sung-Soo Oh: Department of Occupational and Environmental Medicine, Institute of Occupational and Environmental Medicine, Wonju College of Medicine, Yonsei University, Wonju 26426, Korea
Sang-Baek Koh: Department of Preventive Medicine, Wonju College of Medicine, Yonsei University, Wonju 26426, Korea

IJERPH, 2022, vol. 19, issue 12, 1-14

Abstract: Diabetes and prediabetes (called abnormal glucose regulation (AGR)) are adverse health effects associated with exposure to pesticides. However, there are few epidemiological studies on the relationship between pesticide use and the incidence of AGR. We examined the causal relationship between pesticide use and AGR incidence in a rural population using data from a Korean Farmers’ Cohort study of 1076 participants. Poisson regression with robust error variance was used to calculate the relative risks (RR) and 95% confidence intervals (CI) to estimate the relationship between pesticide exposure and AGR. The incidence of AGR in the pesticide-exposed group was 29.1%. Pesticide use increased the RR of AGR (RR 1.32, 95% CI 1.03–1.69). We observed a low-dose effect related to exposure of pesticides to AGR and a U-shaped dose–response relationship in men. Pesticide exposure is related to the incidence of AGR, and the causal relationship differs between men and women.

Keywords: pesticide exposure; diabetes mellitus; prediabetes; abnormal glucose regulation; longitudinal study; incidence; rural (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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