Probiotic Monotherapy with Lactobacillus reuteri (Prodentis) as a Coadjutant to Reduce Subgingival Dysbiosis in a Patient with Periodontitis

Claudia Salinas-Azuceno, Miryam Martínez-Hernández, José-Isaac Maldonado-Noriega, Adriana-Patricia Rodríguez-Hernández and Laurie-Ann Ximenez-Fyvie
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Claudia Salinas-Azuceno: Laboratorio de Genética Molecular, Facultad de Odontología, Universidad Nacional Autónoma de México (UNAM), Ciudad de México 04360, Mexico
Miryam Martínez-Hernández: Laboratorio de Genética Molecular, Facultad de Odontología, Universidad Nacional Autónoma de México (UNAM), Ciudad de México 04360, Mexico
José-Isaac Maldonado-Noriega: Centro de Estudios Superiores de Ortodoncia (CESO), Nicolás San Juan 1628, Ciudad de México 03100, Mexico
Adriana-Patricia Rodríguez-Hernández: Laboratorio de Genética Molecular, Facultad de Odontología, Universidad Nacional Autónoma de México (UNAM), Ciudad de México 04360, Mexico
Laurie-Ann Ximenez-Fyvie: Laboratorio de Genética Molecular, Facultad de Odontología, Universidad Nacional Autónoma de México (UNAM), Ciudad de México 04360, Mexico

IJERPH, 2022, vol. 19, issue 13, 1-12

Abstract: (1) Background: Probiotics can be considered a non-invasive periodontal monotherapy for the modulation of microbiota when periodontal treatment is not accessible. The aim was to evaluate the ability of Lactobacillus reuteri Prodentis as monotherapy to modulate periodontal parameters and subgingival biofilm dysbiosis. (2) Methods: A 30-year-old patient with periodontitis was followed longitudinally after one month of daily consumption of L. reuteri Prodentis (T0). Periodontal measurements and microbial identification by Checkerboard DNA–DNA hybridization of 40 bacteria were compared between baseline (T0) and 30 days (T1) or 90 days (T2), using the Kruskal–Wallis (KW) and Mann–Whitney U (MW) tests. (3) Results: Low values of pocket depth, attachment level, dental plaque, gingival erythema (GE), and suppuration were observed at T0 vs. T1, with the clinical improvement of GE ( p < 0.05, MW) and the recovery of tooth 46 fistulation. T1 vs. T0 comparisons showed lower levels (Lev) or proportions (Prop) of Parvimonas micra (Lev: p < 0.05, MW; Prop: p < 0.01, MW) and Streptococcus gordonii (Prop: p < 0.05, MW), and a predominance (Lev/Prop) of Actinomyces odontolyticus and Streptococcus mitis ; lower levels and proportions of P. micra , Eubacterium saburreum , Porphyromonas gingivalis , and Tannerella forsythia were observed in tooth 46 (T1/T2 vs. T0). (4) Conclusions: Under monotherapy with L. reuteri Prodentis, periodontal measurements of the patient were maintained, with selective changes in the subgingival microbiota that were proportional to the time of probiotic administration, with any additional periodontal treatment.

Keywords: oral probiotics; Lactobacillus reuteri Prodentis; periodontitis; DNA–DNA hybridization; subgingival dysbiosis (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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