Contribution of n-3 Long-Chain Polyunsaturated Fatty Acids to the Prevention of Breast Cancer Risk Factors

Mostefa Fodil, Vincent Blanckaert, Lionel Ulmann, Virginie Mimouni and Benoît Chénais
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Mostefa Fodil: Biology of Organisms: Stress, Health, Environment (BiOSSE), UFR Sciences et Techniques, Le Mans Université, F-72085 Le Mans, France
Vincent Blanckaert: Biology of Organisms: Stress, Health, Environment (BiOSSE), Institut Universitaire de Technologie, Département Génie Biologique, Le Mans Université, F-53020 Laval, France
Lionel Ulmann: Biology of Organisms: Stress, Health, Environment (BiOSSE), Institut Universitaire de Technologie, Département Génie Biologique, Le Mans Université, F-53020 Laval, France
Virginie Mimouni: Biology of Organisms: Stress, Health, Environment (BiOSSE), Institut Universitaire de Technologie, Département Génie Biologique, Le Mans Université, F-53020 Laval, France
Benoît Chénais: Biology of Organisms: Stress, Health, Environment (BiOSSE), UFR Sciences et Techniques, Le Mans Université, F-72085 Le Mans, France

IJERPH, 2022, vol. 19, issue 13, 1-19

Abstract: Nowadays, diet and breast cancer are studied at different levels, particularly in tumor prevention and progression. Thus, the molecular mechanisms leading to better knowledge are deciphered with a higher precision. Among the molecules implicated in a preventive and anti-progressive way, n-3 long chain polyunsaturated fatty acids (n-3 LC-PUFAs) are good candidates. These molecules, like docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids, are generally found in marine material, such as fat fishes or microalgae. EPA and DHA act as anti-proliferative, anti-invasive, and anti-angiogenic molecules in breast cancer cell lines, as well as in in vivo studies. A better characterization of the cellular and molecular pathways involving the action of these fatty acids is essential to have a realistic image of the therapeutic avenues envisaged behind their use. This need is reinforced by the increase in the number of clinical trials involving more and more n-3 LC-PUFAs, and this, in various pathologies ranging from obesity to a multitude of cancers. The objective of this review is, therefore, to highlight the new elements showing the preventive and beneficial effects of n-3 LC-PUFAs against the development and progression of breast cancer.

Keywords: docosahexaenoic acid; eicosapentaenoic acid; cancer therapy; cancer prevention; angiogenesis; apoptosis; cell migration; cell proliferation (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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