Novel Options to Counteract Oral Biofilm Formation: In Vitro Evidence

Alessandra Odorici, Bruna Colombari, Pierantonio Bellini, Aida Meto, Irene Venturelli and Elisabetta Blasi
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Alessandra Odorici: School of Doctorate in Clinical and Experimental Medicine, Laboratory of Microbiology and Virology, University of Modena and Reggio Emilia, Via G. Campi 287, 41125 Modena, Italy
Bruna Colombari: Department of Surgery, Medicine, Dentistry and Morphological Sciences with Interest in Transplant, Oncology and Regenerative Medicine, Laboratory of Microbiology and Virology, University of Modena and Reggio Emilia, Via G. Campi 287, 41125 Modena, Italy
Pierantonio Bellini: Department of Surgery, Medicine, Dentistry and Morphological Sciences with Interest in Transplant, Oncology and Regenerative Medicine, Laboratory of Microbiology and Virology, University of Modena and Reggio Emilia, Via G. Campi 287, 41125 Modena, Italy
Aida Meto: Department of Dentistry, Faculty of Dental Sciences, University of Aldent, 1007 Tirana, Albania
Irene Venturelli: School of Specialization in Microbiology and Virology, University of Modena and Reggio Emilia, Via G. Campi 287, 41125 Modena, Italy
Elisabetta Blasi: Department of Surgery, Medicine, Dentistry and Morphological Sciences with Interest in Transplant, Oncology and Regenerative Medicine, Laboratory of Microbiology and Virology, University of Modena and Reggio Emilia, Via G. Campi 287, 41125 Modena, Italy

IJERPH, 2022, vol. 19, issue 13, 1-6

Abstract: Biofilm production on biotic and abiotic surfaces is crucial in the pathogenesis of most infections, particularly those occurring in the oral cavity. Its prevention and/or control may greatly facilitate the management of patients with oral diseases. Here, the antibiofilm activity of a biomimetic hydroxyapatite and a natural compound, MicroRepair (MicroR) and pomegranate (PomeGr), respectively, was assessed. By luminescence/fluorescence-based assays, Pseudomonas aeruginosa ( P. aeruginosa ), Staphylococcus aureus ( S. aureus ) and Candida albicans ( C. albicans ) were tested for biofilm production in the presence of MicroR and/or PomeGr. We found that both MicroR and PomeGr could affected biofilm production; however, the efficacy of the two, given alone or in combination, varied according to the microbial agent considered. These data open to clinical studies aimed at defining the most efficacious protocols to counteract oral biofilm-associated infections.

Keywords: microbial biofilm; biomimetic hydroxyapatite; MicroRepair; pomegranate extract; antimicrobial compounds (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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