Does Older Age Modify Associations between Endocrine Disrupting Chemicals and Fecundability?

Anna Z. Pollack, Jenna R. Krall, Shanna H. Swan and Germaine M. Buck Louis
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Anna Z. Pollack: Department of Global and Community Health, College of Health and Human Services, George Mason University, Fairfax, VA 22030, USA
Jenna R. Krall: Department of Global and Community Health, College of Health and Human Services, George Mason University, Fairfax, VA 22030, USA
Shanna H. Swan: Department of Preventive Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Germaine M. Buck Louis: Department of Global and Community Health, College of Health and Human Services, George Mason University, Fairfax, VA 22030, USA

IJERPH, 2022, vol. 19, issue 13, 1-11

Abstract: Urinary concentrations of several endocrine disrupting chemicals, including phthalate metabolites, bisphenol A (BPA), and benzophenone (BP)-type ultraviolet (UV) filters, have been associated with a longer time-to-pregnancy (TTP). Potential modification of these associations by couple’s age has not been studied. TTP was defined as the number of prospectively observed menstrual cycles a couple attempted pregnancy until the occurrence of a human chorionic gonadotropic-detected pregnancy. Urinary concentrations of two BP-type UV filters and three phthalate metabolites were measured at baseline. Fecundability odds ratios (FORs) and 95% confidence intervals (CIs) were estimated for each chemical adjusting for age, body mass index, serum cotinine, creatinine, and accounting for right censoring and left truncation. Models evaluated effect modification between EDC concentrations and TTP by partner’s age, dichotomized at 35 years. Separate models were run for male and female partners. No significant effect modification was observed for any EDC for either partner, but data were suggestive of a longer TTP among females aged ≥35 years, particularly for BP-2 (FOR = 0.61, 95% CI 0.36, 1.05) and 4-hydroxybenzophenone (FOR = 0.71, 95% CI: 0.46, 1.09) reflecting 39% and 29% reductions in fecundability, respectively. We saw no evidence of effect modification by couples’ age on associations between TTP and urinary phthalate or BPA metabolite concentrations. Across the EDCs we examined, we found little evidence that age modifies TTP-exposure associations.

Keywords: bisphenol; benzophenone; couples; endocrine disrupting; effect modification; fertility; phthalate; ultraviolet filter (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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