Cytokine Profile in Patients with Multiple Sclerosis Following Exercise: A Systematic Review of Randomized Clinical Trials

Parisa Najafi, Maryam Hadizadeh, Jadeera Phaik Geok Cheong, Hamidreza Mohafez and Suhailah Abdullah
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Parisa Najafi: Centre for Sport and Exercise Sciences, Universiti Malaya, Kuala Lumpur 50603, Malaysia
Maryam Hadizadeh: Centre for Sport and Exercise Sciences, Universiti Malaya, Kuala Lumpur 50603, Malaysia
Jadeera Phaik Geok Cheong: Centre for Sport and Exercise Sciences, Universiti Malaya, Kuala Lumpur 50603, Malaysia
Hamidreza Mohafez: Department of Biomedical Engineering, Faculty of Engineering, Universiti Malaya, Kuala Lumpur 50603, Malaysia
Suhailah Abdullah: Department of Medicine, Faculty of Medicine, Universiti Malaya, Kuala Lumpur 50603, Malaysia

IJERPH, 2022, vol. 19, issue 13, 1-15

Abstract: Multiple sclerosis (MS) is one of the most prevalent causes of nontraumatic neurological impairment in young adults. This review aims to determine the impact of exercise on cytokine and adipokine profile levels as inflammatory markers in MS patients across various exercise paradigms. We used specific keywords in PubMed, Web of Science, The Cochrane Library, and Scopus to find randomized clinical trials addressing the effects of physical activity and exercise training on inflammatory markers levels in MS patients. The majority of the research showed no considerable changes in IL-6 levels, while three studies reported declining levels after the intervention. Approximately half of the trials observed a change in TNF-α and IL-10 levels after exercise interventions, while the other half showed no meaningful changes. Other markers such as IL-17, IL-4, IL-12, adipokines, and BDNF showed fluctuations in levels. We found no universal agreement on the effects of different exercise training protocols on the serum level of inflammatory markers in patients with MS. More research is needed to fully identify the effects of exercise on cytokines in MS patients.

Keywords: multiple sclerosis; inflammatory markers; demyelinating autoimmune diseases; exercise; rehabilitation; cytokine; interleukins; tumor necrosis factor alpha (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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