Obstructive Sleep Apnea and Nonalcoholic Fatty Liver Disease in the General Population: A Cross-Sectional Study Using Nationally Representative Data

Taeyun Kim, Hyunji Choi, Jaejun Lee and Jehun Kim
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Taeyun Kim: Division of Pulmonology, Department of Internal Medicine, The Armed Forces Goyang Hospital, Goyang 10271, Korea
Hyunji Choi: Department of Laboratory Medicine, Industry-Academic Cooperation Foundation of Kosin University, Busan 49104, Korea
Jaejun Lee: Division of Hepatology, Department of Internal Medicine, The Armed Forces Goyang Hospital, Goyang 10271, Korea
Jehun Kim: Division of Pulmonology, Department of Internal Medicine, Kosin University Gospel Hospital, Busan 49267, Korea

IJERPH, 2022, vol. 19, issue 14, 1-12

Abstract: (1) Background: To evaluate the association between obstructive sleep apnea (OSA) and nonalcoholic fatty liver disease (NAFLD) in the general population using a nationally representative sample from South Korea; (2) Methods: This study included 4275 adults aged ≥40 years who completed the snoring, tiredness, observed apnea, high blood pressure, body mass index (BMI), age, neck circumference, and gender (STOP-Bang) questionnaire. The risk of OSA was stratified into low, intermediate, and high grades according to the STOP-Bang score. The prevalence of NAFLD according to the STOP-Bang score was calculated, and the increasing trend was measured. A complex sample multivariable regression analysis with adjustments for possible confounding variables was used to calculate the odds ratio of NAFLD and advanced fibrosis. Subgroup analysis was conducted with stratification based on sex and obesity status; (3) Results: We identified 1021 adults with NAFLD and 3254 adults without NAFLD. The prevalence of NAFLD increased significantly with higher STOP-Bang scores in both men and women. Participants of both sexes with high STOP-Bang scores were more likely to have NAFLD. Compared to non-obese individuals, the risk of NAFLD according to the STOP-Bang score was more intense in obese individuals. With respect to hepatic steatosis, there was no significant association between advanced fibrosis and STOP-Bang score; (4) Conclusions: OSA, the risk of which was measured using the STOP-Bang model, was closely associated with NAFLD in both Korean men and women. Clinicians should consider screening for NAFLD in individuals with a high STOP-Bang score.

Keywords: obstructive sleep apnea; STOP-Bang; NAFLD; fibrosis; KNHANES (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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