Impact of the COVID-19 Pandemic on Pulmonary Hypertension Patients: Insights from the BNP-PL National Database

Aleksandra Mamzer, Marcin Waligora, Grzegorz Kopec, Katarzyna Ptaszynska-Kopczynska, Marcin Kurzyna, Szymon Darocha, Michal Florczyk, Ewa Mroczek, Tatiana Mularek-Kubzdela, Anna Smukowska-Gorynia, Michal Wrotynski, Lukasz Chrzanowski, Olga Dzikowska-Diduch, Katarzyna Perzanowska-Brzeszkiewicz, Piotr Pruszczyk, Ilona Skoczylas, Ewa Lewicka, Piotr Blaszczak, Danuta Karasek, Beata Kusmierczyk-Droszcz, Katarzyna Mizia-Stec, Karol Kaminski, Wojciech Jachec, Malgorzata Peregud-Pogorzelska, Anna Doboszynska, Zbigniew Gasior, Michal Tomaszewski, Agnieszka Pawlak, Wieslawa Zablocka, Robert Ryczek, Katarzyna Widejko-Pietkiewicz and Jaroslaw D. Kasprzak
Additional contact information
Aleksandra Mamzer: 1st Department of Cardiology, Bieganski Hospital, Medical University of Lodz, ul. Kniaziewicza 1/5, 91-347 Lodz, Poland
Marcin Waligora: Pulmonary Circulation Centre, Department of Cardiac and Vascular Diseases, Jagiellonian University Medical College, John Paul II Hospital in Krakowul, Pradnicka 80, 31-202 Krakow, Poland
Grzegorz Kopec: Pulmonary Circulation Centre, Department of Cardiac and Vascular Diseases, Jagiellonian University Medical College, John Paul II Hospital in Krakowul, Pradnicka 80, 31-202 Krakow, Poland
Katarzyna Ptaszynska-Kopczynska: Department of Cardiology, Medical University of Bialystok, 15-276 Bialystok, Poland
Marcin Kurzyna: Department of Pulmonary Circulation, Thromboembolic Diseases and Cardiology, Centre of Postgraduate Medical Education, European Health Centre, 05-400 Otwock, Poland
Szymon Darocha: Department of Pulmonary Circulation, Thromboembolic Diseases and Cardiology, Centre of Postgraduate Medical Education, European Health Centre, 05-400 Otwock, Poland
Michal Florczyk: Department of Pulmonary Circulation, Thromboembolic Diseases and Cardiology, Centre of Postgraduate Medical Education, European Health Centre, 05-400 Otwock, Poland
Ewa Mroczek: Institute of Heart Diseases, University Clinical Hospital Mikulicz Radecki in Wroclaw, ul. Borowska 213, 50-558 Wroclaw, Poland
Tatiana Mularek-Kubzdela: Department of Cardiology, Poznan University of Medical Sciences, 61-701 Poznan, Poland
Anna Smukowska-Gorynia: Department of Cardiology, Poznan University of Medical Sciences, 61-701 Poznan, Poland
Michal Wrotynski: Department of Cardiology, Poznan University of Medical Sciences, 61-701 Poznan, Poland
Lukasz Chrzanowski: 1st Department of Cardiology, Bieganski Hospital, Medical University of Lodz, ul. Kniaziewicza 1/5, 91-347 Lodz, Poland
Olga Dzikowska-Diduch: Department of Internal Medicine and Cardiology, Medical University of Warsaw, 02-005 Warsaw, Poland
Katarzyna Perzanowska-Brzeszkiewicz: Department of Internal Medicine and Cardiology, Medical University of Warsaw, 02-005 Warsaw, Poland
Piotr Pruszczyk: Department of Internal Medicine and Cardiology, Medical University of Warsaw, 02-005 Warsaw, Poland
Ilona Skoczylas: 3rd Department of Cardiology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 41-800 Katowice, Poland
Ewa Lewicka: Department of Cardiology and Electrotherapy, Medical University of Gdansk, 80-211 Gdansk, Poland
Piotr Blaszczak: Department of Cardiology, Cardinal Wyszynski Hospital, 20-718 Lublin, Poland
Danuta Karasek: 2nd Department of Cardiology, Faculty of Health Sciences, Collegium Medicum, Nicolaus Copernicus University, 85-168 Bydgoszcz, Poland
Beata Kusmierczyk-Droszcz: Department of Congenital Heart Disease, Institute of Cardiology, 04-628 Warsaw, Poland
Katarzyna Mizia-Stec: 1st Department of Cardiology, School of Medicine in Katowice, Medical University of Silesia, 41-800 Katowice, Poland
Karol Kaminski: Department of Population Medicine and Civilization Diseases Prevention, Medical University of Bialystok, 15-269 Bialystok, Poland
Wojciech Jachec: 2nd Department of Cardiology, School of Medicine with Dentistry Division in Zabrze, Medical University of Silesia in Katowice, 41-800 Zabrze, Poland
Malgorzata Peregud-Pogorzelska: Department of Cardiology, Pomeranian Medical University, 70-111 Szczecin, Poland
Anna Doboszynska: Pulmonary Department, University of Warmia and Mazury, 10-357 Olsztyn, Poland
Zbigniew Gasior: Department of Cardiology, School of Health Sciences, Medical University of Silesia in Katowice, 40-635 Katowice, Poland
Michal Tomaszewski: Department of Cardiology, Medical University of Lublin, 20-090 Lublin, Poland
Agnieszka Pawlak: Department of Invasive Cardiology, Polish Academy of Sciences, Mossakowski Medical Research Centre, Central Clinical Hospital of the Ministry of Interior, 02-507 Warsaw, Poland
Wieslawa Zablocka: Department of Invasive Cardiology and Cardiology, Independent Public Provincial Complex Hospital in Szczecin, 71-455 Szczecin, Poland
Robert Ryczek: Department of Cardiology and Internal Medicine, Military Institute of Medicine in Warsaw, 04-141 Warsaw, Poland
Katarzyna Widejko-Pietkiewicz: Department of Cardiology, Copper Health Center, 59-300 Lubin, Poland
Jaroslaw D. Kasprzak: 1st Department of Cardiology, Bieganski Hospital, Medical University of Lodz, ul. Kniaziewicza 1/5, 91-347 Lodz, Poland

IJERPH, 2022, vol. 19, issue 14, 1-9

Abstract: We aimed to evaluate the clinical course and impact of the SARS-CoV-2 pandemic on the rate of diagnosis and therapy in the complete Polish population of patients (pts) with pulmonary arterial hypertension (PAH-1134) and CTEPH (570 pts) treated within the National Health Fund program and reported in the national BNP-PL database. Updated records of 1704 BNP-PL pts collected between March and December 2020 were analyzed with regard to incidence, clinical course and mortality associated with COVID-19. Clinical characteristics of the infected pts and COVID-19 decedents were analyzed. The rates of new diagnoses and treatment intensification in this period were studied and collated to the proper intervals of the previous year. The incidence of COVID-19 was 3.8% (n = 65) (PAH, 4.1%; CTEPH, 3.2%). COVID-19-related mortality was 28% (18/65 pts). Those who died were substantially older and had a more advanced functional WHO class and more cardiovascular comorbidities (comorbidity score, 4.0 ± 2.1 vs. 2.7 ± 1.8; p = 0.01). During the pandemic, annualized new diagnoses of PH diminished by 25–30% as compared to 2019. A relevant increase in total mortality was also observed among the PH pts (9.7% vs. 5.9% pre-pandemic, p = 0.006), whereas escalation of specific PAH/CTEPH therapies occurred less frequently (14.7% vs. 21.6% pre-pandemic). The COVID-19 pandemic has affected the diagnosis and treatment of PH by decreasing the number of new diagnoses, escalating therapy and enhancing overall mortality. Pulmonary hypertension is a risk factor for worsened course of COVID-19 and elevated mortality.

Keywords: pulmonary hypertension; SARS-CoV-2; COVID-19; incidence; mortality; BNP-PL database (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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