Interobserver Agreement and Reference Intervals for Biventricular Myocardial Deformation in Full-Term, Healthy Newborns: A 2D Speckle-Tracking Echocardiography-Based Strain Analysis

Daniela Toma, Rodica Toganel, Amalia Fagarasan, Manuela Cucerea, Dorottya Gabor-Miklosi, Andreea Cerghit-Paler, Diana-Ramona Iurian, Horea Gozar, Elena Moldovan, Mihaela Iancu and Liliana Gozar
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Daniela Toma: Department of Pediatric Cardiology, Emergency Institute for Cardiovascular Diseases and Transplantation, 540136 Targu Mures, Romania
Rodica Toganel: Department of Pediatrics, “George Emil Palade” University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540139 Targu Mures, Romania
Amalia Fagarasan: Department of Pediatric Cardiology, Emergency Institute for Cardiovascular Diseases and Transplantation, 540136 Targu Mures, Romania
Manuela Cucerea: Department of Neonatology, County Emergency Hospital Targu Mures, 540136 Targu Mures, Romania
Dorottya Gabor-Miklosi: Department of Pediatric Cardiology, Emergency Institute for Cardiovascular Diseases and Transplantation, 540136 Targu Mures, Romania
Andreea Cerghit-Paler: Department of Pediatric Cardiology, Emergency Institute for Cardiovascular Diseases and Transplantation, 540136 Targu Mures, Romania
Diana-Ramona Iurian: Department of Pediatric Cardiology, Emergency Institute for Cardiovascular Diseases and Transplantation, 540136 Targu Mures, Romania
Horea Gozar: Department of Pediatric Surgery, “George Emil Palade” University of Medicine, Pharmacy, Science and Technology of Targu Mures, 540139 Targu Mures, Romania
Elena Moldovan: Pediatric Intensive Care Unit, Emergency Institute for Cardiovascular Diseases and Transplantation, 540136 Targu Mures, Romania
Mihaela Iancu: Department of Medical Informatics and Biostatistics, Faculty of Medicine, “Iuliu Hațieganu” University of Medicine and Pharmacy Cluj-Napoca, 400012 Cluj-Napoca, Romania
Liliana Gozar: Department of Pediatric Cardiology, Emergency Institute for Cardiovascular Diseases and Transplantation, 540136 Targu Mures, Romania

IJERPH, 2022, vol. 19, issue 14, 1-13

Abstract: Data regarding reference intervals for strain parameters derived from 2D speckle-tracking echocardiography in full-term newborns are limited and still under development. Our objectives were to establish the level of reproducibility and reference intervals in assessing myocardial function using 2D speckle-tracking echocardiography for longitudinal and regional strain measurements. A total of 127 full-term newborns were examined to be included in the study, of which 103 were analyzed. We used two-dimensional acquisitions from apical four-chamber view of both ventricles and analyzed the autostrain function offline. We obtained interobserver agreement between the two observers ranging from good to excellent for all speckle-tracking parameters except for the strain of the medial portion of the left ventricle (LV) lateral wall and the strain measured on the basal portion of the inter-ventricular septum, which reflected a fair interobserver reproducibility (ICC = 0.52, 95% IC: 0.22–0.72 and ICC = 0.43, 95% IC: 0.12–0.67, respectively). The reference values obtained for the LV peak longitudinal strain were between −24.65 and −14.62, those for the right ventricle (RV) free wall were from −28.69 to −10.68, and those for the RV global four-chamber were from −22.30 to −11.37. In conclusion, two-dimensional peak longitudinal LV and RV strains are reproducible with good to excellent agreement and may represent a possible alternative for the cardiac assessment of healthy newborns in the clinical practice.

Keywords: myocardial strain; speckle tracking; newborn; echocardiography (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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