HBM4EU Diisocyanates Study—Research Protocol for a Collaborative European Human Biological Monitoring Study on Occupational Exposure

Kate Jones, Karen S. Galea, Bernice Scholten, Marika Loikala, Simo P. Porras, Radia Bousoumah, Sophie Ndaw, Elizabeth Leese, Henriqueta Louro, Maria João Silva, Susana Viegas, Lode Godderis, Jelle Verdonck, Katrien Poels, Thomas Gӧen, Radu-Corneliu Duca, Tiina Santonen and Diisocyanates Study Team Hbm4eu
Additional contact information
Kate Jones: Health & Safety Executive, Buxton SK17 9JN, UK
Karen S. Galea: Institute of Occupational Medicine (IOM), Edinburgh EH14 4AP, UK
Bernice Scholten: Organization for Applied Scientific Research (TNO), NL-3700 AJ Zeist, The Netherlands
Marika Loikala: Finnish Institute of Occupational Health (FIOH), Työterveyslaitos, FI-00032 Helsinki, Finland
Simo P. Porras: Finnish Institute of Occupational Health (FIOH), Työterveyslaitos, FI-00032 Helsinki, Finland
Radia Bousoumah: French National Research and Safety Institute, 54500 Vandoeuvre-les-Nancy, France
Sophie Ndaw: French National Research and Safety Institute, 54500 Vandoeuvre-les-Nancy, France
Elizabeth Leese: Health & Safety Executive, Buxton SK17 9JN, UK
Henriqueta Louro: National Institute of Health Dr. Ricardo Jorge (INSA), 1649-016 Lisbon, Portugal
Maria João Silva: National Institute of Health Dr. Ricardo Jorge (INSA), 1649-016 Lisbon, Portugal
Susana Viegas: Public Health Research Centre, NOVA National School of Public Health, Universidade NOVA de Lisboa, 1600-560 Lisbon, Portugal
Lode Godderis: Centre for Environment and Health, Department of Public Health and Primary Care, KU Leuven (University of Leuven), 3000 Leuven, Belgium
Jelle Verdonck: Centre for Environment and Health, Department of Public Health and Primary Care, KU Leuven (University of Leuven), 3000 Leuven, Belgium
Katrien Poels: Centre for Environment and Health, Department of Public Health and Primary Care, KU Leuven (University of Leuven), 3000 Leuven, Belgium
Thomas Gӧen: Institute and Outpatient Clinic of Occupational (IPASUM), Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany
Radu-Corneliu Duca: Centre for Environment and Health, Department of Public Health and Primary Care, KU Leuven (University of Leuven), 3000 Leuven, Belgium
Tiina Santonen: Finnish Institute of Occupational Health (FIOH), Työterveyslaitos, FI-00032 Helsinki, Finland
Diisocyanates Study Team Hbm4eu: HBM4EU Diisocyanates Study Team members are listed in Acknowledgments.

IJERPH, 2022, vol. 19, issue 14, 1-11

Abstract: Diisocyanates have long been a leading cause of occupational asthma in Europe, and recently, they have been subjected to a restriction under the REACH regulations. As part of the European Human Biomonitoring project (HBM4EU), we present a study protocol designed to assess occupational exposure to diisocyanates in five European countries. The objectives of the study are to assess exposure in a number of sectors that have not been widely reported on in the past (for example, the manufacturing of large vehicles, such as in aerospace; the construction sector, where there are potentially several sources of exposure (e.g., sprayed insulation, floor screeds); the use of MDI-based glues, and the manufacture of spray adhesives or coatings) to test the usability of different biomarkers in the assessment of exposure to diisocyanates and to provide background data for regulatory purposes. The study will collect urine samples (analysed for diisocyanate-derived diamines and acetyl–MDI–lysine), blood samples (analysed for diisocyanate-specific IgE and IgG antibodies, inflammatory markers, and diisocyanate-specific Hb adducts for MDI), and buccal cells (micronucleus analysis) and measure fractional exhaled nitric oxide. In addition, occupational hygiene measurements (air monitoring and skin wipe samples) and questionnaire data will be collected. The protocol is harmonised across the participating countries to enable pooling of data, leading to better and more robust insights and recommendations.

Keywords: diisocyanates; regulation; biomarkers; exposure assessment; workers (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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