Night Shift Work Is Associated with Reduced Rate of Humoral Response Following Vaccination for HBV

Luca Coppeta, Cristiana Ferrari, Marco Trabucco Aurilio, Gianluigi Ferrazza, Andrea Magrini and Stefano Rizza
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Luca Coppeta: Department of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy
Cristiana Ferrari: School of Occupational Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
Marco Trabucco Aurilio: Department of Medicine and Health Sciences “V. Tiberio”, University of Molise, 86100 Campobasso, Italy
Gianluigi Ferrazza: Department of System Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
Andrea Magrini: Department of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy
Stefano Rizza: Department of System Medicine, University of Rome Tor Vergata, 00133 Rome, Italy

IJERPH, 2022, vol. 19, issue 14, 1-7

Abstract: Night shift work has been associated with cardiovascular and metabolic disease, endocrine and immunological disorders. Published studies have reported that a reduced total sleep time with sleep-wake cycle alterations were associated with a reduced rate of humoral response following vaccination. Our study aimed to evaluate the association between night shift work and serological status for HBV among workers employed in a university hospital in Rome. We evaluated medical records of 986 HCWs working at Tor Vergata Policlinic of Rome. We screened all study subjects for anti-HBs IgG, anti-HBc IgG and HBsAg. Serological protection for HBV was evaluated in relation to sex, age group, job task, risk setting and night shift work status. Protective titer was found in 856 (86.8%) study participants and the mean titer was significantly high in females, in subjects aged less than 40 years, in night shift workers and in high-risk setting workers. After adjustment for study covariates, night shift work was no longer associated with an HBV-protective titer. This finding suggests that a vaccination strategy for dampening HBV transmission should be carefully addressed in health care workers (HCWs) doing night shift.

Keywords: HBV; healthcare workers; vaccination; night shift; shift work; immunological memory (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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