Bone Infarcts and Tumorigenesis—Is There a Connection? A Mini-Mapping Review

Wojciech Konarski, Tomasz Poboży, Martyna Hordowicz, Andrzej Śliwczyński, Ireneusz Kotela, Jan Krakowiak and Andrzej Kotela
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Wojciech Konarski: Department of Orthopaedic Surgery, Ciechanów Hospital, 06-400 Ciechanów, Poland
Tomasz Poboży: Department of Orthopaedic Surgery, Ciechanów Hospital, 06-400 Ciechanów, Poland
Martyna Hordowicz: General Psychiatry Unit III, Dr Barbara Borzym’s Independent Public Regional Psychiatric Health Care Center, 26-600 Radom, Poland
Andrzej Śliwczyński: Department of Social and Preventive Medicine, Social Medicine Institute, Medical University of Lodz, 90-647 Lodz, Poland
Ireneusz Kotela: Department of Orthopedic Surgery and Traumatology, Central Research Hospital of Ministry of Interior, Wołoska 137, 02-507 Warsaw, Poland
Jan Krakowiak: Department of Social and Preventive Medicine, Social Medicine Institute, Medical University of Lodz, 90-647 Lodz, Poland
Andrzej Kotela: Faculty of Medicine, Collegium Medicum, Cardinal Stefan Wyszynski University in Warsaw, Woycickiego 1/3, 01-938 Warsaw, Poland

IJERPH, 2022, vol. 19, issue 15, 1-15

Abstract: (1) Background: Avascular necrosis (AVN) may affect every part of the bone. Epiphyseal infarcts are likely to be treated early because most are symptomatic. However, meta- and diaphyseal infarcts are silent and are diagnosed incidentally. Sarcomas developing in the necrotic bone are extremely rare, but they have been reported in the literature. (2) Methods: We conducted a mapping review of recent evidence regarding these malignancies. Methods: A mapping review using a systematic search strategy was conducted to answer research questions. We limited our research to the last ten years (2012–2022). (3) Results: A total of 11 papers were identified, including 9 case reports and 3 case series. The pathomechanism of carcinogenesis in AVN was not investigated to date. Histologically, most tumors were malignant fibrous histiocytoma. The prognosis is relatively poor, especially for patients with metastases, but adjuvant chemotherapy may increase short- and long-term survival. (4) Conclusions: Since AVN-related malignancies are sporadic, no prospective studies have been conducted. The majority of evidence comes from small case series. More research is needed to identify the risk factors that would justify follow-up of patients after bone infarcts at higher risk of developing a malignancy.

Keywords: secondary osteosarcoma; bone infarct; avascular necrosis; mapping review; infarct associated sarcoma; epidemiology; imaging (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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