Innovative In Vitro Strategy for Assessing Aluminum Bioavailability in Oral Care Cosmetics

Giorgia Allaria, Giulia De Negri Atanasio, Tommaso Filippini, Federica Robino, Lorenzo Dondero, Francesco Soggia, Francesca Rispo, Francesca Tardanico, Sara Ferrando, Stefano Aicardi, Ilaria Demori, Jan Markus, Katia Cortese, Matteo Zanotti-Russo and Elena Grasselli
Additional contact information
Giorgia Allaria: Department of Earth, Environmental, and Life Sciences (DISTAV), University of Genoa, 16132 Genoa, Italy
Giulia De Negri Atanasio: Department of Earth, Environmental, and Life Sciences (DISTAV), University of Genoa, 16132 Genoa, Italy
Tommaso Filippini: CREAGEN—Environmental, Genetic and Nutritional Epidemiology Research Center, Section of Public Health, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy
Federica Robino: Angel Consulting Via San Senatore 14, 20122 Milano, Italy
Lorenzo Dondero: Department of Earth, Environmental, and Life Sciences (DISTAV), University of Genoa, 16132 Genoa, Italy
Francesco Soggia: Department of Chemistry and Industrial Chemistry, University of Genoa, Via Dodecaneso 31, 16146 Genoa, Italy
Francesca Rispo: Department of Earth, Environmental, and Life Sciences (DISTAV), University of Genoa, 16132 Genoa, Italy
Francesca Tardanico: Department of Earth, Environmental, and Life Sciences (DISTAV), University of Genoa, 16132 Genoa, Italy
Sara Ferrando: Department of Earth, Environmental, and Life Sciences (DISTAV), University of Genoa, 16132 Genoa, Italy
Stefano Aicardi: Department of Earth, Environmental, and Life Sciences (DISTAV), University of Genoa, 16132 Genoa, Italy
Ilaria Demori: Department of Earth, Environmental, and Life Sciences (DISTAV), University of Genoa, 16132 Genoa, Italy
Jan Markus: MatTek In Vitro Life Science Laboratories, 82105 Bratislava, Slovakia
Katia Cortese: Cellular Electron Microscopy Laboratory, Department of Experimental Medicine (DIMES), Human Anatomy, University of Genoa, 16132 Genoa, Italy
Matteo Zanotti-Russo: Angel Consulting Via San Senatore 14, 20122 Milano, Italy
Elena Grasselli: Department of Earth, Environmental, and Life Sciences (DISTAV), University of Genoa, 16132 Genoa, Italy

IJERPH, 2022, vol. 19, issue 15, 1-13

Abstract: Aluminum is an element found in nature and in cosmetic products. It can interfere with the metabolism of other cations, thus inducing gastrointestinal disorder. In cosmetics, aluminum is used in antiperspirants, lipsticks, and toothpastes. The aim of this work is to investigate aluminum bioavailability after accidental oral ingestion derived from the use of a toothpaste containing a greater amount of aluminum hydroxide than advised by the Scientific Committee on Consumer Safety (SCCS). To simulate in vitro toothpaste accidental ingestion, the INFOGEST model was employed, and the amount of aluminum was measured through the ICP-AES analysis. Tissue barrier integrity was analyzed by measuring transepithelial electric resistance, and the tissue architecture was checked through light microscopy. The margin of safety was also calculated. Overall, our results indicate that the acute exposure to aluminum accidentally ingested from toothpastes is safe for the final user, even in amounts higher than SCCS indications.

Keywords: aluminum; oral care cosmetics; bioavailability; margin of safety; next-generation risk assessment (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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