Short-Term Effects of Side-Stream Smoke on Nerve Growth Factor and Its Receptors TrKA and p75 NTR in a Group of Non-Smokers

Anna Maria Stabile (), Alessandra Pistilli, Desirée Bartolini, Eleonora Angelucci, Marco Dell’Omo, Gabriele Di Sante and Mario Rende
Additional contact information
Anna Maria Stabile: Department of Medicine and Surgery, Section of Human Anatomy, Clinical and Forensic, School of Medicine, University of Perugia, P. le Lucio Severi 1 Sant’Andrea delle Fratte, 06132 Perugia, Italy
Alessandra Pistilli: Department of Medicine and Surgery, Section of Human Anatomy, Clinical and Forensic, School of Medicine, University of Perugia, P. le Lucio Severi 1 Sant’Andrea delle Fratte, 06132 Perugia, Italy
Desirée Bartolini: Department of Medicine and Surgery, Section of Human Anatomy, Clinical and Forensic, School of Medicine, University of Perugia, P. le Lucio Severi 1 Sant’Andrea delle Fratte, 06132 Perugia, Italy
Eleonora Angelucci: Department of Medicine, Section of Occupational Medicine, Respiratory Diseases and Toxicology, School of Medicine, University of Perugia, Lucio Severi 1 Sant’Andrea delle Fratte, 06132 Perugia, Italy
Marco Dell’Omo: Department of Medicine, Section of Occupational Medicine, Respiratory Diseases and Toxicology, School of Medicine, University of Perugia, Lucio Severi 1 Sant’Andrea delle Fratte, 06132 Perugia, Italy
Gabriele Di Sante: Department of Medicine and Surgery, Section of Human Anatomy, Clinical and Forensic, School of Medicine, University of Perugia, P. le Lucio Severi 1 Sant’Andrea delle Fratte, 06132 Perugia, Italy
Mario Rende: Department of Medicine and Surgery, Section of Human Anatomy, Clinical and Forensic, School of Medicine, University of Perugia, P. le Lucio Severi 1 Sant’Andrea delle Fratte, 06132 Perugia, Italy

IJERPH, 2022, vol. 19, issue 16, 1-11

Abstract: Environmental tobacco smoke remains a major risk factor, for both smokers and non-smokers, able to trigger the initiation and/or the progression of several human diseases. Although in recent times governments have acted with the aim of banning or strongly reducing its impact within public places and common spaces, environmental tobacco smoke remains a major pollutant in private places, such as the home environment or cars. Several inflammatory and long-term biomarkers have been analysed and well-described, but the list of mediators modulated during the early phases of inhalation of environmental tobacco smoke needs to be expanded. The aim of this study was to measure the short-term effects after exposure to side-stream smoke on Nerve Growth Factor and its receptors Tropomyosin-related kinase A and neurotrophin p75, molecules already described in health conditions and respiratory diseases. Twenty-one non-smokers were exposed to a home-standardized level of SS as well as to control smoke-free air. Nerve Growth Factor and inflammatory cytokines levels, as well the expression of Tropomyosin-related kinase A and neurotrophin receptor p75, were analysed in white blood cells. The present study demonstrates that during early phases, side-stream smoke exposure induced increases in the percentage of neurotrophin receptor p75-positive white blood cells, in their mean fluorescent intensity, and in gene expression. In addition, we found a positive correlation between the urine cotinine level and the percentage of neurotrophin receptor-positive white blood cells. For the first time, the evidence that short-term exposure to side-stream smoke is able to increase neurotrophin receptor p75 expression confirms the very early involvement of this receptor, not only among active smokers but also among non-smokers exposed to SS. Furthermore, the correlation between cotinine levels in urine and the increase in neurotrophin receptor p75-positive white blood cells could represent a potential novel molecule to be investigated for the detection of SS exposure at early time points.

Keywords: side-stream smoke; nerve growth factor; neurotrophin receptor p75; tropomyosin-related kinase A; cotinine; second-hand smoke; environmental tobacco smoke (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/19/16/10317/pdf (application/pdf)
https://www.mdpi.com/1660-4601/19/16/10317/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:19:y:2022:i:16:p:10317-:d:892274

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().