Endometrial Cancer in Aspect of Forkhead Box Protein Contribution

Olga Adamczyk-Gruszka (), Agata Horecka-Lewitowicz, Jakub Gruszka, Monika Wawszczak-Kasza, Agnieszka Strzelecka and Piotr Lewitowicz
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Olga Adamczyk-Gruszka: Department of Gynaecology and Obstetrics, Collegium Medicum, Jan Kochanowski University, 25-369 Kielce, Poland
Agata Horecka-Lewitowicz: Institute of Health Sciences, Jan Kochanowski University, 25-369 Kielce, Poland
Jakub Gruszka: 2nd Department of Obstetrics and Gynaecology, Medical University of Warsaw, 02-091 Warsaw, Poland
Monika Wawszczak-Kasza: Department of Surgical Medicine with the Laboratory of Medical Genetics, Institute of Medical Sciences, Jan Kochanowski University, 25-369 Kielce, Poland
Agnieszka Strzelecka: Institute of Health Sciences, Jan Kochanowski University, 25-369 Kielce, Poland
Piotr Lewitowicz: Department of Clinical and Experimental Pathology, Institute of Medical Sciences, Jan Kochanowski University, 25-369 Kielce, Poland

IJERPH, 2022, vol. 19, issue 16, 1-7

Abstract: (1) Background: The present study aimed to investigate the influence of forkhead box (FOX) on endometrial cancer (EC) progression. For a better understanding, the driving mechanisms are vital to identifying correlations between genes and their regulators. (2) Methods: The study enrolled one hundred and three white female patients with confirmed EC. For the analysis, we used next-generation sequencing with the Hot Spot Cancer Panel provided by Illumina Inc., San Diego, CA, USA, and an immunohistochemical analysis of FOXA1, FOXP1, and estrogen receptors. (3) Results: FOXA1 silencing led to a worse outcome based on the correlation with FOXA1 (test log-rank p = 0.04220 and HR 2.66, p = 0.033). Moreover, FOX proteins were closely correlated with TP53 and KRAS mutation. (4) Conclusions: Our study confirmed previous reports about FOX box protein in the regulation of tumor growth. A remarkable observation about the unclear crosstalk with crucial genes, as TP53 and KRAS need deeper investigation.

Keywords: endometrial cancer; microsatellite instability; immunohistochemistry; Illumina sequencing (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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