Effects of Tartrazine on Some Sexual Maturation Parameters in Immature Female Wistar Rats

Elisabeth Louise Ndjengue Mindang (), Charline Florence Awounfack, Derek Tantoh Ndinteh, Rui W. M. Krause and Dieudonne Njamen ()
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Elisabeth Louise Ndjengue Mindang: Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, Yaounde P.O. Box 812, Cameroon
Charline Florence Awounfack: Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, Yaounde P.O. Box 812, Cameroon
Derek Tantoh Ndinteh: Department of Chemical Sciences, Faculty of Science, University of Johannesburg, Johannesburg P.O. Box 17011, South Africa
Rui W. M. Krause: Department of Chemistry, Faculty of Chemical and Pharmaceutical Sciences, Rhodes University, Makhanda P.O. Box 94, South Africa
Dieudonne Njamen: Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, Yaounde P.O. Box 812, Cameroon

IJERPH, 2022, vol. 19, issue 16, 1-14

Abstract: Over the past century, the average age for onset of puberty has declined. Several additives present in our food are thought to contribute significantly to this early puberty which is recognized to also affect people’s health in later life. On this basis, the impact of 40-days unique oral administration of the food dye tartrazine (7.5, 27, and 47 mg/kg BW doses) was evaluated on some sexual maturation parameters on immature female Wistar rats. Vaginal opening was evaluated during the treatment period. At the end of the treatments, animals were sacrificed (estrus phase) and the relative weight of reproductive organs, pituitary gonadotrophin and sexual steroids level, cholesterol level in ovaries and folliculogenesis were evaluated. Compared to the control group, animals receiving tartrazine (47 mg/kg BW) showed significantly high percentage of early vaginal opening from day 45 of age, and an increase in the number of totals, primaries, secondaries, and antral follicles; a significant increase in serum estrogen, LH and in uterine epithelial thickness. Our findings suggest that tartrazine considerably disturbs the normal courses of puberty. These results could validate at least in part the global observations on increasingly precocious puberty in girls feeding increasingly with industrially processed foods.

Keywords: food additive; tartrazine; rat; early puberty; folliculogenesis; endocrine disruptor (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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