Acute and Subchronic Oral Toxicity of Anthraquinone in Sprague Dawley Rats

Jingjing Qu, Lanjie Pei, Xiangyan Wang, Shaohua Fu, Ling Yong, Xiao Xiao, Qianqian Xie, Bolin Fan () and Yan Song ()
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Jingjing Qu: Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China
Lanjie Pei: Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China
Xiangyan Wang: Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China
Shaohua Fu: Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China
Ling Yong: Key Laboratory of Food Safety Risk Addessment, National Health and Family Planning Commission of the People’s Republic of China (China National Center for Food Safety Risk Assessment), Beijing 100022, China
Xiao Xiao: Key Laboratory of Food Safety Risk Addessment, National Health and Family Planning Commission of the People’s Republic of China (China National Center for Food Safety Risk Assessment), Beijing 100022, China
Qianqian Xie: Key Laboratory of Food Safety Risk Addessment, National Health and Family Planning Commission of the People’s Republic of China (China National Center for Food Safety Risk Assessment), Beijing 100022, China
Bolin Fan: Hubei Provincial Key Laboratory for Applied Toxicology, Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China
Yan Song: Key Laboratory of Food Safety Risk Addessment, National Health and Family Planning Commission of the People’s Republic of China (China National Center for Food Safety Risk Assessment), Beijing 100022, China

IJERPH, 2022, vol. 19, issue 16, 1-16

Abstract: Objective: This study was conducted to evaluate the acute and subchronic toxicity of anthraquinone. An acute toxicity test was performed in female Sprague Dawley (SD) rats, and the oral median lethal dose (LD 50 ) of anthraquinone was estimated to be >5000 mg/kg body weight (BW). In the subchronic study, groups of 10 male and 10 female rats were dosed with anthraquinone by gavage at 0, 1.36, 5.44, 21.76, and 174.08 mg/kg BW, 7 days/week for 90 days followed by a recovery period of 28 days. No appreciable toxic-related changes were observed in the 1.36 mg/kg BW group. When the animals received 5.44 mg/kg BW or more of anthraquinone, hyaline droplet accumulation in the renal tubules was observed in both the male and female rats, and anemia was observed in the females. When the anthraquinone dose reached 174.08 mg/kg BW, mild hepatocellular hypertrophy around the central vein of the hepatic lobule and hypothyroidism were observed in the female rats. During the recovery period, changes in clinical symptoms and parameters were considerably alleviated. Based on the results of this study, the no observed adverse effect level (NOAEL) for anthraquinone in rats was set at 1.36 mg/kg BW, and the lowest observed adverse effect level (LOAEL) was 5.44 mg/kg BW.

Keywords: anthraquinone; acute toxicity; subchronic toxicity; Sprague Dawley rats (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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