Antimicrobial, Multi-Drug and Colistin Resistance in Enterobacteriaceae in Healthy Pigs in the Greater Accra Region of Ghana, 2022: A Cross-Sectional Study

Rita Ohene Larbi (), Wisdom Adeapena, Matilda Ayim-Akonor, Ebenezer D. O. Ansa, Hannock Tweya, Robert Fraser Terry, Appiah-Korang Labi and Anthony D. Harries
Additional contact information
Rita Ohene Larbi: CSIR—Animal Research Institute, P.O. Box AH 20 Achimota-Accra, Greater Accra Region, Ghana
Wisdom Adeapena: Kintampo Health Research Centre, P.O. Box 200, Kintampo, Bono East Region, Ghana
Matilda Ayim-Akonor: CSIR—Animal Research Institute, P.O. Box AH 20 Achimota-Accra, Greater Accra Region, Ghana
Ebenezer D. O. Ansa: CSIR—Animal Research Institute, P.O. Box AH 20 Achimota-Accra, Greater Accra Region, Ghana
Hannock Tweya: Malawi International Training and Education Center for Health (Malawi-I-TECH), Lilongwe P.O. Box 30369, Malawi
Robert Fraser Terry: Special Programme for Research and Training in Tropical Diseases, World Health Organization, 1211 Geneva, Switzerland
Appiah-Korang Labi: WHO Country Office, P.O. Box MB 142, 7 Ameda Street, Roman Ridge-Accra, Greater Accra Region, Ghana
Anthony D. Harries: Centre for Operational Research, International Union Against Tuberculosis and Lung Disease (The Union), 75001 Paris, France

IJERPH, 2022, vol. 19, issue 16, 1-14

Abstract: There is little published information on antimicrobial resistance (AMR) in animals in Ghana. We determined the prevalence and factors associated with AMR, multi-drug resistance (MDR-resistance to ≥3 antimicrobial classes) and colistin resistance in Enterobacteriaceae in healthy pigs in Accra, Ghana. Rectal swabs obtained from the pigs on 20 farms from January to March 2022, were examined for Escherichia coli , Enterobacter spp. and Klebsiella pneumoniae . AMR was determined using standard microbiological techniques and the mcr-1 gene detected through molecular analysis. Enterobacteriaceae were isolated from 197 of 200 pigs: these comprised 195 E. coli isolates, 38 Enterobacter spp. and 3 K. pneumoniae , either singly or combined. Over 60% of E. coli were resistant to tetracycline, with 27% and 34% being resistant to amoxicillin/clavulanic acid and ampicillin, respectively; 23% of E. coli and 5% of Enterobacter spp. exhibited MDR phenotypes. Phenotypic colistin resistance was found in 8% of E. coli and Enterobacter spp., with the mcr-1 gene detected in half. Our study findings should be incorporated into on-going AMR, MDR and colistin resistance surveillance programs in Ghana. We further advocate for tailored-specific education for pig farmers on animal antimicrobial use and for strengthened regulatory policy on antimicrobial usage and monitoring in the animal production industry.

Keywords: farms in Ghana; antimicrobial use; Escherichia coli; Klebsiella pneumoniae; Enterobacter spp.; antimicrobial resistance (AMR); mcr-1 gene; operational research; SORT IT (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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