The Clinical Significance of Urinary Retinol-Binding Protein 4: A Review

Krzysztof Ratajczyk, Andrzej Konieczny, Adrian Czekaj, Paweł Piotrów, Marek Fiutowski, Kornelia Krakowska, Paweł Kowal, Wojciech Witkiewicz and Karolina Marek-Bukowiec ()
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Krzysztof Ratajczyk: Department of Urology, Regional Specialist Hospital in Wroclaw, Kamienskiego 73a, 51-124 Wroclaw, Poland
Andrzej Konieczny: Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland
Adrian Czekaj: Department of Urology, Regional Specialist Hospital in Wroclaw, Kamienskiego 73a, 51-124 Wroclaw, Poland
Paweł Piotrów: Department of Urology, Regional Specialist Hospital in Wroclaw, Kamienskiego 73a, 51-124 Wroclaw, Poland
Marek Fiutowski: Department of Urology, Regional Specialist Hospital in Wroclaw, Kamienskiego 73a, 51-124 Wroclaw, Poland
Kornelia Krakowska: Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland
Paweł Kowal: Department of Urology, Regional Specialist Hospital in Wroclaw, Kamienskiego 73a, 51-124 Wroclaw, Poland
Wojciech Witkiewicz: Research and Development Center, Regional Specialist Hospital in Wroclaw, Kamienskiego 73a, 51-124 Wroclaw, Poland
Karolina Marek-Bukowiec: Research and Development Center, Regional Specialist Hospital in Wroclaw, Kamienskiego 73a, 51-124 Wroclaw, Poland

IJERPH, 2022, vol. 19, issue 16, 1-13

Abstract: Effective biomarkers for early diagnosis, prognostication, and monitoring in renal diseases (in general) comprise an unmet need. Urinary retinol-binding protein 4, which is the most sensitive indicator of renal tubular damage, holds great promise as a universal biomarker for renal pathologies, in which tubular injury is the driving force. Here, we summarize the most important existing data on the associations between urinary retinol-binding protein 4 and renal diseases and highlight the untapped potential of retinol-binding protein 4 in clinical use.

Keywords: urinary RBP4; renal diseases; biomarker (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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