Six HIT Sessions Improve Cardiorespiratory Fitness and Metabolic Flexibility in Insulin Resistant and Insulin Sensitive Adolescents with Obesity

Juliana Monique Lino Aparecido (), Marcelo Luis Marquezi, Hellyelson Lopes de Omena Couto, Thais Miriã da Silva Santos, Alison Fabiano Cunha Cruz, Nayara Barbosa Lopes, Marcelo Santin Cascapera, Vivian Bertoni Xavier, Cristiane Kochi, Vera Lúcia dos Santos Alves and Antonio Herbert Lancha
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Juliana Monique Lino Aparecido: Laboratory of Physical Education Research (LAPEF), University City of Sao Paulo (UNICID), Sao Paulo 05508-030, Brazil
Marcelo Luis Marquezi: Laboratory of Physical Education Research (LAPEF), University City of Sao Paulo (UNICID), Sao Paulo 05508-030, Brazil
Hellyelson Lopes de Omena Couto: Laboratory of Physical Education Research (LAPEF), University City of Sao Paulo (UNICID), Sao Paulo 05508-030, Brazil
Thais Miriã da Silva Santos: Laboratory of Physical Education Research (LAPEF), University City of Sao Paulo (UNICID), Sao Paulo 05508-030, Brazil
Alison Fabiano Cunha Cruz: Laboratory of Physical Education Research (LAPEF), University City of Sao Paulo (UNICID), Sao Paulo 05508-030, Brazil
Nayara Barbosa Lopes: Laboratory of Physical Education Research (LAPEF), University City of Sao Paulo (UNICID), Sao Paulo 05508-030, Brazil
Marcelo Santin Cascapera: Pediatric Cardiology Group, Department of Pediatrics, Childcare of Irmandade da Santa Casa de Misericórdia de São Paulo (ISCMSP), Sao Paulo 01221-010, Brazil
Vivian Bertoni Xavier: Santa Casa de Sao Paulo School of Medical Sciences, Sao Paulo 01221-010, Brazil
Cristiane Kochi: Molecular Medicine Laboratory, Department of Pediatrics, Childcare of Irmandade da Santa Casa de Misericórdia de São Paulo (ISCMSP), Santa Casa de Sao Paulo School of Medical Sciences, Sao Paulo 01221-010, Brazil
Vera Lúcia dos Santos Alves: Physiotherapy Service, Irmandade da Santa Casa de Misericórdia de São Paulo, Postgraduate—Universidade de Mogi das Cruzes (UMC), Sao Paulo 01221-010, Brazil
Antonio Herbert Lancha: Laboratory of Clinical Investigation Experimental Surgery (LIM 26), Clinic’s Hospital of Medical School, University of Sao Paulo, Sao Paulo 05508-030, Brazil

IJERPH, 2022, vol. 19, issue 17, 1-12

Abstract: To evaluate the effect of high-intensity interval training (HIT) on the cardiorespiratory performance and substrate oxidation pattern in insulin-resistant and insulin-sensitive obese adolescents. Methods: We recruited 25 obese adolescents in three schools, and trained them in six HIT sessions, comprising of six series at 100% and recovery at 50% peak velocity (Vpeak). For the evaluation, the participants were divided into two groups: insulin-resistant (IR, n = 12; HOMA index ≥3.16) and insulin-sensitive (IS, n = 13). All participants underwent cardiopulmonary and indirect calorimetry testing. We compared the effects of HIT before and after the intervention among the two groups. The data were analyzed using Student’s t and Mann–Whitney (intergroup comparisons) and Student’s t and Wilcoxon (pre- and post-training comparisons) tests; and Cohen’s d (influence of HIT). Results: There was a significant post-training increase in Vpeak, oxygen consumption (VO2), velocity (V), and heart rate (HR) at the exertion intensity at the first ventilatory anaerobic threshold (VAT1) in both groups ( p < 0.05; d < 0.02). The exercise promoted changes in substrate oxidation rates of the groups, with an increase in carbohydrate oxidation (CHOox) for both IR ( p = 0.064) and IS ( p = 0.034). Conclusion: Six HIT sessions improved cardiorespiratory performance in both groups and increased CHOox in insulin-sensitive obese adolescents, suggesting its utility for increasing physical fitness and controlling glycemia in these population groups.

Keywords: obesity; insulin-resistant; adolescents; high-intensity interval training (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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