Psychopathological Impact in Patients with History of Rheumatic Fever with or without Sydenham’s Chorea: A Multicenter Prospective Study

Alessandro Orsini, Thomas Foiadelli, Attilio Sica (), Andrea Santangelo, Niccolò Carli, Alice Bonuccelli, Rita Consolini, Sofia D’Elios, Nicolò Loddo, Alberto Verrotti, Giuseppe Di Cara, Chiara Marra, Maria Califano, Anna Fetta, Marianna Fabi, Stefania Bergamoni, Aglaia Vignoli, Roberta Battini, Marta Mosca, Chiara Baldini, Nadia Assanta, Pietro Marchese, Gabriele Simonini, Edoardo Marrani, Francesca Felicia Operto, Grazia Maria Giovanna Pastorino, Salvatore Savasta, Giuseppe Santangelo, Virginia Pedrinelli, Gabriele Massimetti, Liliana Dell’Osso, Diego Peroni, Duccio Maria Cordelli, Martina Corsi and Claudia Carmassi
Additional contact information
Alessandro Orsini: Pediatric Neurology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa, 56121 Pisa, Italy
Thomas Foiadelli: Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, University of Pavia, 27100 Pavia, Italy
Attilio Sica: Pediatric Neurology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa, 56121 Pisa, Italy
Andrea Santangelo: Pediatric Neurology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa, 56121 Pisa, Italy
Niccolò Carli: Pediatric Neurology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa, 56121 Pisa, Italy
Alice Bonuccelli: Pediatric Neurology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa, 56121 Pisa, Italy
Rita Consolini: Pediatric Neurology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa, 56121 Pisa, Italy
Sofia D’Elios: Pediatric Neurology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa, 56121 Pisa, Italy
Nicolò Loddo: Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, University of Pavia, 27100 Pavia, Italy
Alberto Verrotti: Department of Pediatrics, University of Perugia, 06123 Perugia, Italy
Giuseppe Di Cara: Department of Pediatrics, University of Perugia, 06123 Perugia, Italy
Chiara Marra: Child Neurology Unit, University of Bologna, 40126 Bologna, Italy
Maria Califano: Child Neurology Unit, University of Bologna, 40126 Bologna, Italy
Anna Fetta: Child Neurology Unit, University of Bologna, 40126 Bologna, Italy
Marianna Fabi: Child Neurology Unit, University of Bologna, 40126 Bologna, Italy
Stefania Bergamoni: Childhood and Adolescence Neurology and Psychiatry Unit, ASST GOM Niguarda, 20121 Milan, Italy
Aglaia Vignoli: Childhood and Adolescence Neurology and Psychiatry Unit, ASST GOM Niguarda, 20121 Milan, Italy
Roberta Battini: Department of Clinical and Experimental Medicine, University of Pisa, 56121 Pisa, Italy
Marta Mosca: Department of Clinical and Experimental Medicine, University of Pisa, 56121 Pisa, Italy
Chiara Baldini: Department of Clinical and Experimental Medicine, University of Pisa, 56121 Pisa, Italy
Nadia Assanta: Heart Hospital, G. Monasterio Tuscan Foundation, 54100 Massa, Italy
Pietro Marchese: Heart Hospital, G. Monasterio Tuscan Foundation, 54100 Massa, Italy
Gabriele Simonini: Pediatric Rheumatology, Meyer Children Hospital, University of Florence, 50134 Florence, Italy
Edoardo Marrani: Pediatric Rheumatology, Meyer Children Hospital, University of Florence, 50134 Florence, Italy
Francesca Felicia Operto: Child and Adolescent Neuropsychiatry Unit, Department of Medicine, Surgery and Dentistry, University of Salerno, 84084 Baronissi, Italy
Grazia Maria Giovanna Pastorino: Child and Adolescent Neuropsychiatry Unit, Department of Medicine, Surgery and Dentistry, University of Salerno, 84084 Baronissi, Italy
Salvatore Savasta: Pediatric Clinic, ASST di Crema, 26013 Crema, Italy
Giuseppe Santangelo: Child Neuropsychiatry Unit, ISMEP—P.O. Cristina—ARNAS Civico, Via dei Benedettini 1, 90100 Palermo, Italy
Virginia Pedrinelli: Department of Clinical and Experimental Medicine, University of Pisa, 56121 Pisa, Italy
Gabriele Massimetti: Department of Clinical and Experimental Medicine, University of Pisa, 56121 Pisa, Italy
Liliana Dell’Osso: Department of Clinical and Experimental Medicine, University of Pisa, 56121 Pisa, Italy
Diego Peroni: Pediatric Neurology, Pediatric University Department, Azienda Ospedaliera Universitaria Pisana, University of Pisa, 56121 Pisa, Italy
Duccio Maria Cordelli: Child Neurology Unit, University of Bologna, 40126 Bologna, Italy
Martina Corsi: Occupational Health Department, Azienda Ospedaliero Universitaria Pisana, Via Paradisa 2, 56124 Pisa, Italy
Claudia Carmassi: Department of Clinical and Experimental Medicine, University of Pisa, 56121 Pisa, Italy

IJERPH, 2022, vol. 19, issue 17, 1-13

Abstract: Sydenham’s chorea (SC) is a post-streptococcal autoimmune disorder of the central nervous system, and it is a major criterium for the diagnosis of acute rheumatic fever (ARF). SC typically improves in 12–15 weeks, but patients can be affected for years by persistence and recurrencies of both neurological and neuropsychiatric symptoms. We enrolled 48 patients with a previous diagnosis of ARF, with or without SC, in a national multicenter prospective study, to evaluate the presence of neuropsychiatric symptoms several years after SC’s onset. Our population was divided in a SC group (n = 21), consisting of patients who had SC, and a nSC group (n = 27), consisting of patients who had ARF without SC. Both groups were evaluated by the administration of 8 different neuropsychiatric tests. The Work and Social Adjustment Scale (WSAS) showed significantly ( p = 0.021) higher alterations in the SC group than in the nSC group. Furthermore, 60.4% (n = 29) of the overall population experienced neuropsychiatric symptoms other than choreic movements at diagnosis and this finding was significantly more common ( p = 0.00) in SC patients (95.2%) than in nSC patients (33.3%). The other neuropsychiatric tests also produced significant results, indicating that SC can exert a strong psychopathological impact on patients even years after its onset.

Keywords: Sydenham’s chorea; acute rheumatic fever; neuropsychiatric tests; persistent and recurrent chorea (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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