Association between Bone-Related Physiological Substances and Oral Function in Community-Dwelling Older People

Misa Nakamura (), Masakazu Imaoka, Fumie Tazaki, Hidetoshi Nakao, Mitsumasa Hida, Ryohei Kono, Hideki Kanemoto and Masatoshi Takeda
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Misa Nakamura: Cognitive Reserve Research Center, Osaka Kawasaki Rehabilitation University, Kaizuka 597-0104, Osaka, Japan
Masakazu Imaoka: Cognitive Reserve Research Center, Osaka Kawasaki Rehabilitation University, Kaizuka 597-0104, Osaka, Japan
Fumie Tazaki: Cognitive Reserve Research Center, Osaka Kawasaki Rehabilitation University, Kaizuka 597-0104, Osaka, Japan
Hidetoshi Nakao: Department of Physical Therapy, Josai International University, Tougane 283-0002, Chiba, Japan
Mitsumasa Hida: Cognitive Reserve Research Center, Osaka Kawasaki Rehabilitation University, Kaizuka 597-0104, Osaka, Japan
Ryohei Kono: Cognitive Reserve Research Center, Osaka Kawasaki Rehabilitation University, Kaizuka 597-0104, Osaka, Japan
Hideki Kanemoto: Department of Psychiatry, Graduate School of Medicine, Osaka University, Suita 565-0871, Osaka, Japan
Masatoshi Takeda: Cognitive Reserve Research Center, Osaka Kawasaki Rehabilitation University, Kaizuka 597-0104, Osaka, Japan

IJERPH, 2022, vol. 19, issue 17, 1-8

Abstract: Background: Oral dysfunction is related to long-term cares including activities of daily living. The objective of this study was to determine the association between oral function and the bone-related physiological substances osteocalcin (OC) and insulin-like growth factor-1 (IGF-1). Methods: The study participants were 139 community-dwelling older people in Japan. Evaluation of oral dysfunction was based on subjective judgment by each participant. Blood analysis included OC, IGF-1, and albumin. Results: Univariate and multiple logistic analyses showed that IGF-1 was significantly associated with a “decline in masticatory function” ( p = 0.0074 and p = 0.0308, respectively). Receiver operating characteristic curve analysis of IGF-1 levels revealed a threshold score of 108 ng/mL ( p < 0.01) for discriminating a “decline in masticatory function”. Logistic regression analysis revealed that participants with an IGF-1 level ≤108 ng/mL had an odds ratio of 4.31 ( p < 0.05) for a “decline in masticatory function”. No significant association was found between the OC level and oral dysfunction. Conclusions: These results suggest a possible relationship between lower serum IGF-1 levels and a decline in masticatory dysfunction in community-dwelling older people.

Keywords: IGF-1; mastication; community-dwelling; older people (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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