The Effect of UV Treatment on Surface Contact Angle, Fibroblast Cytotoxicity, and Proliferation with Two Types of Zirconia-Based Ceramics

Vygandas Rutkunas, Rokas Borusevicius (), Evaldas Balciunas, Urte Jasinskyte, Milda Alksne, Egidijus Simoliunas, Stefan Zlatev, Vasilena Ivanova, Virginija Bukelskiene and Eitan Mijiritsky
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Vygandas Rutkunas: Institute of Odontology, Faculty of Medicine, Vilnius University, 03101 Vilnius, Lithuania
Rokas Borusevicius: Institute of Odontology, Faculty of Medicine, Vilnius University, 03101 Vilnius, Lithuania
Evaldas Balciunas: Institute of Biochemistry, Life Sciences Center, Vilnius University, 03101 Vilnius, Lithuania
Urte Jasinskyte: Institute of Biochemistry, Life Sciences Center, Vilnius University, 03101 Vilnius, Lithuania
Milda Alksne: Institute of Biochemistry, Life Sciences Center, Vilnius University, 03101 Vilnius, Lithuania
Egidijus Simoliunas: Institute of Biochemistry, Life Sciences Center, Vilnius University, 03101 Vilnius, Lithuania
Stefan Zlatev: CAD/CAM Center of Dental Medicine at the Research Institute, Medical University of Plovdiv, 4000 Plovdiv, Bulgaria
Vasilena Ivanova: Oral Surgery Department, Faculty of Dental Medicine, Medical University of Plovdiv, 4000 Plovdiv, Bulgaria
Virginija Bukelskiene: Institute of Biochemistry, Life Sciences Center, Vilnius University, 03101 Vilnius, Lithuania
Eitan Mijiritsky: Head and Neck Maxillofacial Surgery, Tel-Aviv Sourasky Medical Center, Department of Otolaryngology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 699350, Israel

IJERPH, 2022, vol. 19, issue 17, 1-12

Abstract: UV photofunctionalization of Zirconia-based materials for abutment fabrication is a promising approach that might influence the formation of a sound peri-implant seal, thus promoting long-term soft and hard tissue implant integration. This study aimed to evaluate the effect of UV treatment of test specimens made by two different ZnO 2 -based ceramic materials on the hydrophilicity, cell cytotoxicity, and proliferation of human gingival fibroblasts (HGFs). Two Zirconia-based materials, high-translucent and ultra-translucent multi-layered Zirconia (Katana, Kuraray Noritake, Japan), were used to prepare a total of 40 specimens distributed in two equally sized groups based on the material ( n = 20). The same surface finishing protocol was applied for all specimens, as suggested by the manufacturer. Half the specimens from each group were treated with UV-C light for 48 h. Water contact angle (WCA), fibroblast cytotoxicity, and proliferation were investigated. The WCA values for the high-translucent Zirconia ranged from 69.9° ± 6.4° to 73.7° ± 13.9° for the treated/non-treated specimens and from 79.5° ± 12.8° to 83.4° ± 11.4° for the ultra-translucent multi-layered Zirconia, respectively. However, the difference was insignificant (F(16) = 3.50, p = 0.292). No significant difference was observed for the fibroblast cytotoxicity test. The results for proliferation revealed a significant difference, which was material-dependent (F(8) = 9.58, p = 0.005). We found that UV surface photofunctionalization of ZrO 2 -based materials alters the human gingival fibroblast cell viability, which might produce favourable results for cell proliferation.

Keywords: surface roughness; water contact angle; fibroblast proliferation; zirconia; UV photofunctionalization (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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