Genetic Instability among Hitnü People Living in Colombian Crude-Oil Exploitation Areas

Claudia Galeano-Páez (), Dina Ricardo-Caldera, Luisa Jiménez-Vidal, Ana Peñata-Taborda, Andrés Coneo-Pretelt, Margarita Rumié-Mendoza, Alicia Humanez Álvarez, Shirley Salcedo-Arteaga, Gean Arteaga-Arroyo, Karina Pastor-Sierra, Pedro Espitia-Pérez, Paula A. Avilés-Vergara, Catalina Tovar-Acero, Sara Soto- De León, Hugo Brango, Osnamir Elias Bru-Cordero, Marvin Jiménez-Narváez, Elena E. Stashenko, Edna M. Gamboa-Delgado, Alvaro J. Idrovo and Lyda Espitia-Pérez ()
Additional contact information
Claudia Galeano-Páez: Grupo de Investigación Biomédicas y Biología Molecular, Universidad del Sinú E.B.Z., Montería 230001, Colombia
Dina Ricardo-Caldera: Grupo de Investigación Enfermedades Tropicales y Resistencia Bacteriana, Universidad del Sinú E.B.Z., Montería 230001, Colombia
Luisa Jiménez-Vidal: Grupo de Investigación Biomédicas y Biología Molecular, Universidad del Sinú E.B.Z., Montería 230001, Colombia
Ana Peñata-Taborda: Grupo de Investigación Biomédicas y Biología Molecular, Universidad del Sinú E.B.Z., Montería 230001, Colombia
Andrés Coneo-Pretelt: Grupo de Investigación Biomédicas y Biología Molecular, Universidad del Sinú E.B.Z., Montería 230001, Colombia
Margarita Rumié-Mendoza: Grupo de Investigación Biomédicas y Biología Molecular, Universidad del Sinú E.B.Z., Montería 230001, Colombia
Alicia Humanez Álvarez: Grupo de Investigación Biomédicas y Biología Molecular, Universidad del Sinú E.B.Z., Montería 230001, Colombia
Shirley Salcedo-Arteaga: Grupo de Investigación Biomédicas y Biología Molecular, Universidad del Sinú E.B.Z., Montería 230001, Colombia
Gean Arteaga-Arroyo: Grupo de Investigación Biomédicas y Biología Molecular, Universidad del Sinú E.B.Z., Montería 230001, Colombia
Karina Pastor-Sierra: Grupo de Investigación Biomédicas y Biología Molecular, Universidad del Sinú E.B.Z., Montería 230001, Colombia
Pedro Espitia-Pérez: Grupo de Investigación Biomédicas y Biología Molecular, Universidad del Sinú E.B.Z., Montería 230001, Colombia
Paula A. Avilés-Vergara: Grupo de Investigación Enfermedades Tropicales y Resistencia Bacteriana, Universidad del Sinú E.B.Z., Montería 230001, Colombia
Catalina Tovar-Acero: Grupo de Investigación Enfermedades Tropicales y Resistencia Bacteriana, Universidad del Sinú E.B.Z., Montería 230001, Colombia
Sara Soto- De León: Grupo de Investigación Enfermedades Tropicales y Resistencia Bacteriana, Universidad del Sinú E.B.Z., Montería 230001, Colombia
Hugo Brango: Departamento de Matemáticas y Estadística, Universidad del Norte, Barranquilla 080001, Colombia
Osnamir Elias Bru-Cordero: Facultad de Ciencias e Ingenierías, Universidad del Sinú E.B.Z., Montería 230001, Colombia
Marvin Jiménez-Narváez: Grupo GNOXIC, Universidad del Sinú E.B.Z., Montería 230001, Colombia
Elena E. Stashenko: Center for Chromatography and Mass Spectrometry (CROM-MASS), Universidad Industrial de Santander, Bucaramanga 680001, Colombia
Edna M. Gamboa-Delgado: Escuela de Nutrición y Dietética, Universidad Industrial de Santander, Bucaramanga 680001, Colombia
Alvaro J. Idrovo: Public Health Department, School of Medicine, Universidad Industrial de Santander, Bucaramanga 680001, Colombia
Lyda Espitia-Pérez: Grupo de Investigación Biomédicas y Biología Molecular, Universidad del Sinú E.B.Z., Montería 230001, Colombia

IJERPH, 2022, vol. 19, issue 18, 1-17

Abstract: Oil exploitation, drilling, transportation, and processing in refineries produces a complex mixture of chemical compounds, including polycyclic aromatic hydrocarbons (PAHs), which may affect the health of populations living in the zone of influence of mining activities (PZOI). Thus, to better understand the effects of oil exploitation activities on cytogenetic endpoint frequency, we conducted a biomonitoring study in the Hitnü indigenous populations from eastern Colombia by using the cytokinesis micronucleus cytome assay (CBMN-cyt). PAH exposure was also measured by determine urine 1-hydroxypyrene (1-OHP) using HPLC. We also evaluated the relationship between DNA damage and 1-OHP levels in the oil exploitation area, as well as the modulating effects of community health factors, such as Chagas infection; nutritional status; and consumption of traditional hallucinogens, tobacco, and wine from traditional palms. The frequencies of the CBMN-cyt assay parameters were comparable between PZOI and Hitnü populations outside the zone of influence of mining activities (POZOI); however, a non-significant incremental trend among individuals from the PZOI for most of the DNA damage parameters was also observed. In agreement with these observations, levels of 1-OHP were also identified as a risk factor for increased MN frequency (PR = 1.20) compared to POZOI (PR = 0.7). Proximity to oil exploitation areas also constituted a risk factor for elevated frequencies of nucleoplasmic bridges (NPBs) and APOP-type cell death. Our results suggest that genetic instability and its potential effects among Hitnü individuals from PZOI and POZOI could be modulated by the combination of multiple factors, including the levels of 1-OHP in urine, malnutrition, and some traditional consumption practices.

Keywords: Hitnü people; PAH; oil exploitation; CBMN cyt (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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