Impact of Exercise Intensity on Systemic Oxidative Stress, Inflammatory Responses, and Sirtuin Levels in Healthy Male Volunteers

Su-Youn Cho, Young-Soo Chung, Hyoung-Ki Yoon and Hee-Tae Roh ()
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Su-Youn Cho: Exercise Physiology Laboratory, Department of Physical Education, Yonsei University, Seoul 03722, Korea
Young-Soo Chung: Department of Sports and Leisure Studies, School of Arts and Health, Myongji College, Seoul 03656, Korea
Hyoung-Ki Yoon: School of Sports, College of Humanities, Soongsil University, Seoul 06978, Korea
Hee-Tae Roh: Department of Sports Science, College of Health Science, Sun Moon University, 70 Sunmoon-ro 221 beongil, Tangjeong-myeon, Asan-si 31460, Korea

IJERPH, 2022, vol. 19, issue 18, 1-9

Abstract: Exercise can induce anti-inflammatory and antioxidant effects, for which regulation of sirtuins (SIRTs) may be a major consideration for exercise prescription. The purpose of this study was to investigate the effects of acute aerobic exercise, in particular its intensity, on systemic oxidative stress, inflammatory responses, and SIRT levels. Twenty healthy, untrained males were recruited and randomly assigned to moderate-intensity (MI, 65% VO 2 max, n = 10) and high-intensity (HI, 85% VO 2 max, n = 10) exercise. Blood samples were obtained pre-, immediately post-, and 1 h post-exercise for measurements of malonaldehyde (MDA), superoxide dis-mutase (SOD), interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, SIRT-1, SIRT-2, and SIRT-3. Overall, MDA, SOD, IL-6, SIRT-1, and SIRT-3 levels were significantly increased at post-exercise compared with pre-exercise regardless of exercise intensity ( p < 0.05). The HI group had significantly higher MDA, SOD, and IL-6 levels than the MI group at post-exercise ( p < 0.05), whereas no significant differences were observed in the IL-1β, TNF-α, and SIRT-2 levels ( p > 0.05). Altogether, these findings suggest that exercise-induced oxidative stress and inflammatory responses may be dependent on exercise intensity. Moreover, activation of inflammatory cytokines and SIRT family members may be dependent on the intensity of the exercise.

Keywords: acute exercise; redox state; inflammation; sirtuin family (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2022
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